Critical involvement of circular RNAs in virus-associated cancers

作     者：Arghavan Zebardast Tayebeh Latifi Moein shirzad Golnaz Goodarzi Saeed Ebrahimi Fana Sadra Samavarchi Tehrani Yousef Yahyapour Arghavan Zebardast;Tayebeh Latifi;Moein shirzad;Golnaz Goodarzi;Saeed Ebrahimi Fana;Sadra Samavarchi Tehrani;Yousef Yahyapour

作者机构：Department of VirologySchool of Public HealthTehran University of Medical SciencesTehran ***Iran Cellular and Molecular Biology Research CenterHealth Research InstituteBabol University of Medical SciencesBabol 47176Iran Department of Clinical BiochemistrySchool of MedicineTehran University of Medical SciencesTehran ***Iran Student Scientific Research CenterTehran University of Medical SciencesTehran ***Iran Infectious Diseases and Tropical Medicine Research CenterHealth Research InstituteBabol University of Medical SciencesBabol 47176Iran 

出 版 物：《Genes & Diseases》 (基因与疾病（英文）)

年 卷 期：2023年第10卷第6期

页      面：2296-2305页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Cancer Circular RNA Neoplasms Oncogenes Viruses 

摘      要：Virus-related cancer is cancer where viral infection leads to the malignant transformation of the host s infected cells. Seven viruses (e.g., human papillomavirus (HPV), Epstein–Barr virus (EBV), Kaposi s sarcoma herpesvirus (KSHV), Hepatitis B virus (HBV), Hepatitis C virus (HCV), Human T-lymphotropic virus (HTLV), and Merkel cell polyomavirus (MCV)) that infect humans have been identified as an oncogene and have been associated with several human malignancies. Recently, growing attention has been attracted to exploring the pathogenesis of virus-related cancers. One of the most mysterious molecules involved in carcinogenesis and progression of virus-related cancers is circular RNAs (circRNA). These emerging non-coding RNAs (ncRNAs), due to the absence of 5′ and 3′ ends, have high stability than linear RNAs and are found in some species across the eukaryotic organisms. Compelling evidence has revealed that viruses also encode a repertoire of circRNAs, as well as dysregulation of these viral circRNAs play a critical role in the pathogenesis and progression of different types of virus-related cancers. Therefore, understanding the exact role and function of the virally encoded circRNAs with virus-associated cancers will open a new road for increasing our knowledge about the RNA world. Hence, in this review, we will focus on emerging roles of virus-encoded circRNAs in multiple cancers, including cervical cancer, gastric cancer, Merkel cell carcinoma, nasopharyngeal carcinoma, Kaposi cancer, and liver cancer.