Myosin regulates intracellular force and guides collective cancer cell migration via the FAK-Rho/ROCK feedback loop

作     者：Xiang Qin Yuchen He Yixi Zhang Shun Li Tingting Li Fengming You Yiyao Liu Xiang Qin;Yuchen He;Yixi Zhang;Shun Li;Tingting Li;Fengming You;Yiyao Liu

作者机构：Department of PharmacyPersonalized Drug Therapy Key Laboratory of Sichuan ProvinceSichuan Provincial People's HospitalSchool of Life Science and TechnologyUniversity of Electronic Science and Technology of ChinaChengduSichuan 611731China TCM Regulating Metabolic Diseases Key Laboratory of Sichuan ProvinceHospital of Chengdu University of Traditional Chinese MedicineChengduSichuan 610072China 

出 版 物：《Genes & Diseases》 (基因与疾病(英文))

年 卷 期：2023年第10卷第6期

页      面：2199-2201页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported,in part or in whole,by the National Natural Science Foundation of China(No.32071304,U19A2006,12132004,11972111,and 32171309) the China Postdoctoral Science Foundation(No.2019T120821) the Natural Science Foundation of Sichuan Program(No.23NSFSC3552,2022NSFSC0048,2022NSFSC0686,23SYSX0108,and 2023NSFSC1233) the Joint Funds of Center for Engineering Medicine(No.ZYGX2021YGLH017). 

主　　题：cancer collective migration 

摘      要：Breast cancerhas been one of the biggest killers of women due to its susceptibility and high metastasis.Pathological observations show that malignant cancer cells frequently invade the surrounding normal tissue in collective rather than individual cell migration.1,2 For individual cell migration,it has been found that the Rho/ROCK signaling is upregulated and correlates with disease progression.3 Meanwhile,Rho activates myosin-ll and the actomyosin-mediated contraction creates tension within the cells.4,5 However,the roles of the activation of the Rho/RoCK signal pathway in collective cell migration and the precise mechanisms by which myosin-ll fine-tunes the contractility of the cells to allow for the reorganization of the cytoskeleton that drives collective cell migration,remain unclear.This study investigated whether the high cellular contractility could activate the inside-out signal transductions and how did the intracellular force contribute to the collective cell migration.