Role of dendritic cells in MYD88-mediated immune recognition and osteoinduction initiated by the implantation of biomaterials

作     者：Zifan Zhao Qin Zhao Hu Chen Fanfan Chen Feifei Wang Hua Tang Haibin Xia Yongsheng Zhou Yuchun Sun Zifan Zhao;Qin Zhao;Hu Chen;Fanfan Chen;Feifei Wang;Hua Tang;Haibin Xia;Yongsheng Zhou;Yuchun Sun

作者机构：Center of Digital DentistryFaculty of ProsthodonticsPeking University School and Hospital of Stomatology&National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Research Center of Oral Biomaterials and Digital Medical Devices&Beijing Key Laboratory of Digital Stomatology&Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health&NMPA Key Laboratory for Dental MaterialsBeijingChina The State Key Laboratory Breeding Base of Basic Science of Stomatology(Hubei-MOST)&Key Laboratory of Oral BiomedicineMinistry of EducationSchool&Hospital of StomatologyWuhan UniversityWuhanChina Institute of Infection and ImmunityMedical Science and Technology Innovation CenterShandong First Medical University&Shandong Academy of Medical SciencesJinanChina 

出 版 物：《International Journal of Oral Science》 (国际口腔科学杂志（英文版）)

年 卷 期：2023年第15卷第3期

页      面：411-421页

核心收录：

学科分类：1003[医学-口腔医学] 08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 

基　　金：supported by the Beijing Training Project for the Leading Talents in S&T(Grant No.Z191100006119022) the National Key Program of the National Natural Science Foundation of China(Grant No.51705006) Capital’s Funds for Health Improvement and Research(2022-2Z-4106). 

主　　题：implantation biomaterials release 

摘      要：Bone substitute material implantation has become an important treatment strategy for the repair of oral and maxillofacial bone defects.Recent studies have shown that appropriate inflammatory and immune cells are essential factors in the process of osteoinduction of bone substitute materials.Previous studies have mainly focused on innate immune cells such as macrophages.In our previous work,we found that T lymphocytes,as adaptive immune cells,are also essential in the osteoinduction procedure.As the most important antigen-presenting cell,whether dendritic cells(DCs)can recognize non-antigen biomaterials and participate in osteoinduction was still unclear.In this study,we found that surgical trauma associated with materials implantation induces necrocytosis,and this causes the release of high mobility group protein-1(HMGB1),which is adsorbed on the surface of bone substitute materials.Subsequently,HMGB1-adsorbed materials were recognized by the TLR4-MYD88-NFκB signal axis of dendritic cells,and the inflammatory response was activated.Finally,activated DCs release regeneration-related chemokines,recruit mesenchymal stem cells,and initiate the osteoinduction process.This study sheds light on the immune-regeneration process after bone substitute materials implantation,points out a potential direction for the development of bone substitute materials,and provides guidance for the development of clinical surgical methods.