Surface defect engineered-Mg-based implants enable the dual functions of superhydrophobic and synergetic photothermal/chemodynamic therapy

作     者：Dongdong Zhang Ru Xu Shuhan Chen Huihui Du Shi Qian Feng Peng Xuanyong Liu 

作者机构：State Key Laboratory of High Performance Ceramics and Superfine MicrostructureShanghai Institute of CeramicsChinese Academy of SciencesShanghai200050China Center of Materials Science and Optoelectronics EngineeringUniversity of Chinese Academy of SciencesBeijing100049China Shenzhen Key Laboratory for Innovative Technology in Orthopaedic TraumaThe University of Hong Kong Shenzhen HospitalShenzhenChina Center for Human Tissues and Organs DegenerationShenzhen Institutes of Advanced TechnologyChinese Academy of ScienceShenzhen518055PR China Medical Research InstituteDepartment of OrthopedicsGuangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern MedicalUniversityGuangzhou510080China GuangDong Engineering Technology Research Center of Functional Repair of Bone Defects and BiomaterialsGuangzhou510080China School of Chemistry and Materials ScienceHangzhou Institute for Advanced StudyUniversity of Chinese Academy of Sciences1 Sub-lane XiangshanHangzhou310024China 

出 版 物：《Bioactive Materials》 (生物活性材料（英文）)

年 卷 期：2023年第30卷第12期

页      面：15-28页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 

基　　金：the National Key R&D Program of China(2021YFC2400500) Shanghai Committee of Science and Technology,China(20S31901200) GDPH Supporting Fund for Talent Program(KY0120220137 and KY012021462) Postdoctoral Science Foundation of China(2022M723288). 

主　　题：Magnesium-based implants Surface defects Superhydrophobic Anti-bacterial Anti-tumor 

摘      要：Promoting metallic magnesium(Mg)-based implants to treat bone diseases in clinics,such as osteosarcoma and bacterial infection,remains a challenging topic.Herein,an iron hydroxide-based composite coating with a twostage nanosheet-like structure was fabricated on Mg alloy,and this was followed by a thermal reduction treatment to break some of the surface Fe–OH bonds.The coating demonstrated three positive changes in properties due to the defects.First,the removal of–OH made the coating superhydrophobic,and it had self-cleaning and antifouling properties.This is beneficial for keeping the implants clean and for anti-corrosion before implantation into the human body.Furthermore,the superhydrophobicity could be removed by immersing the implant in a 75%ethanol solution,to further facilitate biological action during service.Second,the color of the coating changed from yellow to brown-black,leading to an increase in the light absorption,which resulted in an excellent photothermal effect.Third,the defects increased the Fe2+content in the coating and highly improved peroxidase activity.Thus,the defect coating exhibited synergistic photothermal/chemodynamic therapeutic effects for bacteria and tumors.Moreover,the coating substantially enhanced the anti-corrosion and biocompatibility of the Mg alloys.Therefore,this study offers a novel multi-functional Mg-based implant for osteosarcoma therapy.