Cyclodextrin Based Host-Guest Inclusion Complex, an Approach to Enhancing the Physicochemical and Biopharmaceutical Application of Poorly Water-soluble Drugs

作     者：Muhammad INAM Moshirian-Farahi SAREH SADAT Wenjie CHEN Muhammad INAM;Moshirian-Farahi SAREH SADAT;Wenjie CHEN

作者机构：Key Laboratory of Molecular Target&Clinical Pharmacology and the State&NMOA Key Laboratory of Respiratory DiseaseSchool of Pharmaceutical Science&The Fifth Affiliated HospitalGuangzhou Medical University.Guangzhou511436P.R.China Department of Applied ChemistryMashhad BranchIslamic Azad UniversityMashhadIran Sydney Vital Translational Cancer Research CentreWestbourne StNsw 2065Australia 

出 版 物：《Chemical Research in Chinese Universities》 (高等学校化学研究（英文版）)

年 卷 期：2023年第39卷第6期

页      面：857-861页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070305[理学-高分子化学与物理] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 

基　　金：supported by the Guangdong Postdoctoral Start-up Fund,China(No.Q0301-082) the High-level University Construction Fund of Guangdong Province,China(Nos.02-412-2202-2123,02-410-2206298,02-412-2302-2122xM) the Fund from He Guangzhou Science and Technology Bureau,China(No.202201010378) the Open Project of State Key Laboratory of Respiratory Disease,China(No.SKLRD-OP-202409) 

主　　题：Poor water solubility Inclusion complex Physicochemical Biopharmaceutical 

摘      要：Host-guest inclusion complexes have been extensively studied for drug delivery *** host molecule,typically cyclodextrin,creates a cavity,in which the guest molecule,such as a drug,can be *** encapsulation can protect the drug from degradation,improve its solubility and stability,and enhance its ***,host-guest inclusion complexes can facilitate targeted drug delivery by selectively releasing drugs at the site of *** techniques,such as covalent bonding,non-covalent interactions,and self-assembly have been used to form these ***-guest inclusion complexes have shown great potential for improving the efficacy and safety of drug delivery *** mini review summarizes the application and recent progress of the cyclodextrin-based host-guest inclusion complex,highlighting the enhanced physicochemical and biopharmaceutical application of pharmaceutical drugs via formulation of its inclusion complex.