Efficacy and safety of Weichang’an pill(胃肠安丸)combined with Western Medicine on gastrointestinal diseases:a systematic review and Meta-analysis

作     者：WANG Jiabao ZHANG Lishuang NIU Baihan YU Yajun YANG Fengwen MIAO Lin CHAI Lijuan DING Xinya SUN Yingjie WANG Yujing WANG Lin ZHANG Han WANG Yi LI Lin WANG Jiabao;ZHANG Lishuang;NIU Baihan;YU Yajun;YANG Fengwen;MIAO Lin;CHAI Lijuan;DING Xinya;SUN Yingjie;WANG Yujing;WANG Lin;ZHANG Han;WANG Yi;LI Lin

作者机构：Institute of Traditional Chinese MedicineKey Laboratory of Pharmacology of Traditional Chinese Medical FormulaeState Key Laboratory of Component-based Chinese MedicineTianjin University of Traditional Chinese MedicineTianjin 301617China Department of CardiologyTianjin Binhai New Area Hospital of Traditional Chinese MedicineTianjin 300451China Scientific Research Departmentthe First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou 450000China Tianjin Zhongxin Pharmaceutical Group Co.Ltd.Lerentang Pharmaceutical FactoryTianjin 413204China 

出 版 物：《Journal of Traditional Chinese Medicine》 (中医杂志（英文版）)

年 卷 期：2023年第43卷第6期

页      面：1057-1067页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Training Project of Innovation Team of Colleges and Universities in Tianjin:Study on Compound Chinese Medicine (Grant No.TD13-5053) Scientific Research Project of Tianjin Educational Committee:Research on the Basic Biology of the Wind Drugs Effects of “Dissipate Wind to Dissipate Heat,Dispel Wind to Relieve Pain” via TLR4/NF-κB Signalling Pathway (Grant No.2018KJ007) Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine (Grant No.ZYYCXTD-C-202009) National Natural Science Foundation of China:Research on the Therapeutic Effect and Mechanism of “Wind Dispeling” Herb Vitex Trifolia for Migraine Treatment via CGRP/ERK/NF-κB/NLRP3 Signaling Pathway (No.82004331) National Natural Science Foundation of China:Research on the Effects of Erzhi pills via 11β-HSD1-GC/GR Pathway on Cognitive Function and Its Mechanism of Chronic Mild and Unpredictable Stress Depression Mice (No.81973792) 

主　　题：gastrointestinal disease integrative medicine Meta-analysis systematic review Weichang’an pill 

摘      要：OBJECTIVE:To systematically evaluate the efficacy and safety of Weichang’an pill(胃肠安丸,WCA)combined with Western Medicine(WM)for the treatment of gastrointestinal ***:Eight databases,including China National Knowledge Infrastructure Database,Wanfang Data,China Science and Technology Journal Database,SinoMed,PubMed,Web of Science,Cochrane Library,and Embase,were searched for randomized controlled trials(RCTs)of WCA from inception to 30 September *** independently screened the literature,extracted data,and then evaluated the bias risk,effectiveness,safety,and other indicators of the included ***:A total of 33 RCTs were included in this study with 3368 *** analysis,it was found that WCA combined with WM could effectively prevent and treat antibiotic-associated gastrointestinal reaction,functional dyspepsia(FD),irritable bowel syndrome,rotavirus diarrhea(RVD),and ulcerative colitis(UC);no serious adverse reactions ***,compared with the control group,the experimental group showed significantly improved symptoms and some biochemical ***:WCA combined with WM for the treatment of gastrointestinal diseases had better clinical efficacy than the control group,without serious adverse ***,in the treatment of FD,RVD,and UC,WCA improved clinical symptoms and biochemical indicator ***,owing to the restricted quality and quantity of the literature,the results need to be further studied using high-quality RCTs.