Role of inositol polyphosphate-4-phosphatase type II in oncogenesis of digestive system tumors

作     者：Le Han Shuo Chen Shi-Yu Du 

作者机构：Peking University China-Japan Friendship School of Clinical MedicinePeking UniversityBeijing 100029China Department of GastroenterologyChina-Japan Friendship HospitalBeijing 100029China 

出 版 物：《World Journal of Gastrointestinal Oncology》 (世界胃肠肿瘤学杂志（英文版）（电子版）)

年 卷 期：2023年第15卷第10期

页      面：1706-1716页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：China-Japan Friendship Hospital Foundation  (2019-1-QN-2) 

主　　题：Inositol polyphosphate-4-phosphatase type II Tumors of the digestive system Protein kinase B Serum and glucocorticoid-regulated kinase 3 

摘      要：Inositol polyphosphate-4-phosphatase type II(INPP4B)is a newly discovered PI(3,4,5)P3 *** studies have revealed that INPP4B is upregulated or downregulated in tumors of the digestive system,and the abnormal expression of INPP4B may be attributed to the occurrence,development,and prognosis of tumors of the digestive *** paper reviews studies on the correlations between INPP4B and digestive system tumors and the roles of INPP4B in the development of different tumors to provide a theoretical basis for further research on its molecular mechanism and clinical application.INPP4Bandtumorwere searched as key words in PubMed and in the CNKI series full text database retrieval system from January 2000 to August 2023.A total of 153 Englishlanguage studies and 30 Chinese-language studies were *** following enrollment criteria were applied:(1)Studies contained information on the biological structure and functions of INPP4B;(2)studies covered the influence of abnormal expression of INPP4B in digestive system tumors;and(3)studies covered the role of INPP4B in the diagnosis,treatment,and prognosis of digestive system *** excluding the literature irrelevant to this study,61 papers were finally included in the ***4B expression is low in gastric cancer,colon cancer,pancreatic cancer,and liver cancer but it has high expression in esophageal cancer,colon cancer,pancreatic cancer,and gallbladder ***4B is involved in the occurrence and development of digestive system tumors through the regulation of gene expression and signal *** abnormal expression of INPP4B plays an important role in the development of digestive system *** on INPP4B provide new molecular insights for the diagnosis,treatment,and prognosis evaluation of digestive system tumors.