Engineering of electrospun nanofiber scaffolds for repairing brain injury

作     者：Wenzhe Du Tong Wang Shuyun Hu Jixin Luan Feng Tian Guolin Ma Jiajia Xue 

作者机构：State Key Laboratory of Organic-Inorganic CompositesBeijing University of Chemical TechnologyBeijing 100029PR China Beijing Laboratory of Biomedical MaterialsBeijing University of Chemical TechnologyBeijing 100029PR China Department of RadiologyChina-Japan Friendship HospitalNo.2 East Yinghua RoadChaoyang DistrictBeijing 100029PR China 

出 版 物：《再生工程(英文)》 (Engineered Regeneration)

年 卷 期：2023年第4卷第3期

页      面：289-303页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 08[工学] 

基　　金：supported by the Key Program of Beijing Natural Science Foundation (Grant No.Z200025) National Natural Science Foundation of China (Grant No.52073014,52221006,81971585 and 82271953) Young Scientists Program of the Ministry of Science and Technology (Grant No.2022YFC2408200) supported by the Na-tional Key Research and Development Program of China (Grant No.2020YFC2003903) Guangzhou Science and Technology Planning Project (Grant No.202103010001). 

主　　题：Electrospun nanofibers Brain injury Engineering strategies Neural repair Functional recovery 

摘      要：Patients with brain injury can suffer disability and accompanying complications.Current clinical treatments have significant limitations to successful repair due to the complexity of the pathological processes and the inhibitory microenvironment that follows brain injury.Here,we conclude recent research progresses in engineering strate-gies based on electrospun nanofibers for promoting neural repair and functional recovery after brain injury.Firstly,we introduce the main pathological mechanisms of current brain injuries,pointing out the prospect of the application of electrospun nanofiber scaffolds compared to current clinical treatment strategies.We then discuss the repair strategies combining the structure and the morphology of nanofiber scaffolds with load therapeutic factors such as cells,drugs and growth factors.All of these strategies show potential for improving the repair of brain injury.Finally,we point out the challenges facing the effective treatment of brain injury,aiming to provide insights into the development of repairing scaffolds for brain function recovery from the perspective of clinical treatment.