Steroid and triterpenoid saponins from the rhizomes of Paris polyphylla ***

作     者：HU Jinming LU Yunyang ZHENG Shuxian TIAN Yunyuan LI Tianyi TANG Haifeng YANG Zhao LIU Yang HU Jinming;LU Yunyang;ZHENG Shuxian;TIAN Yunyuan;LI Tianyi;TANG Haifeng;YANG Zhao;LIU Yang

作者机构：Department of Chinese Medical and Natural MedicinesSchool of PharmacyAir Force Medical UniversityXi'an 710032China Department of Military Medical PsychologyAir Force Military Medical UniversityXi'an 70032China 

出 版 物：《Chinese Journal of Natural Medicines》 (中国天然药物（英文版）)

年 卷 期：2023年第21卷第10期

页      面：789-800页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(Nos.81973192 and 81902185) the Key Research and Development Projects of Shaanxi Province(Nos.2021ZDLSF04-07,2021SF-175 and 2022SF-314) the Natural Science Basic Research Program of Shaanxi Province(No.2022JQ-780) the Key Scientific Research Project of Shaanxi Administration of Traditional Chinese Medicine(No.2021-02-ZZ-003) 

主　　题：Paris polyphylla var.stenophylla Steroid saponins Triterpenoid saponins Cyclocholestanol-type 

摘      要：Five new saponins,including three steroid saponins,paristenoids A-C(1-3),and two triterpenoid saponins,paristenoids D-E(4-5),along with four known ones(6-9)were isolated from the rhizomes of Paris polyphylla *** structures of the isolated compounds were identified nainly by detailed spectroscopic analysis,including extensive 1D and 2D NMR,MS,as well as chemical *** 3 is a new cyclocholestanol-type steroidal saponin with a rare 6/6/6/5/5 fused-rings cholestanol skeleton,and this skeleton has been first found from the genus *** cytotoxicities of the isolated compounds against three human three glioma cell lines(U87MG,U251MG and SHG44)were evaluated,and compound 7 displayed certain inhibitory effect with ICso values of 15.22±1.73,18.87±1.81 and 17.64±1.69μmol^(-1),respectively.