放射性药物治疗芯片:微流控驱动的数字孪生在个体化癌症治疗中的展望

作     者：Hamid Abdollahi Babak Saboury Madjid Soltani Kuangyu Shi Carlos Uribe Arman Rahmim 

作者机构：Department of RadiologyUniversity of British ColumbiaVancouver V5Z 1M9Canada Department of Integrative OncologyBC Cancer Research InstituteVancouver V5Z 1L3Canada Department of Radiology and Imaging SciencesClinical CenterNational Institutes of HealthBethesda 20892USA Department of Electrical&Computer EngineeringUniversity of WaterlooWaterloo N2L 3G1Canada Department of Nuclear MedicineInselspitalBern University HospitalUniversity of BernBern 3010Switzerland Computer Aided Medical Procedures and Augmented RealityInstitute of InformaticsTechnical University of MunichMunich 80333Germany Functional ImagingBC CancerVancouver V5Z 4E6Canada Department of Physics&AstronomyUniversity of British ColumbiaVancouver V6T 1Z1Canada 

出 版 物：《科学通报:英文版》 (Science Bulletin)

年 卷 期：2023年第68卷第18期

页      面：1983-1988页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the Canadian Institutes of Health Research (CIHR) Project Grant PJT-162216 Networking Health Ltd 

主　　题：放射性药物 癌症治疗 微流控 

摘      要：Radiopharmaceutical therapy(RPT)has shown great promise in the treatment of various cancers.However,the current approach is aone size fits allmodel,which results in varied patient responses,and there is a need for personalized RPT(Fig.S1 online).This personalized approach requires a better understanding of the physics,biology,radiobiology,pharmacology,immunology,chemistry,and imaging involved in RPT[1].Multidisciplinary research using experimental,numerical,and simulation platforms would be key to accelerating progress in this area.