Synthesis and Evaluation of Aromatic DTPA-bis(amide)Gadolinium Complexes as Magnetic Resonance Imaging Contrast Agents

作     者：ZHUO Ren Xi WEN Jie WANG Lu 

作者机构：Department of ChemistryLaboratory of Biomedical Materials of the State Education Commission of ChinaWuhan UniversityWuhan 430072 

出 版 物：《Chemical Research in Chinese Universities》 (高等学校化学研究(英文版))

年 卷 期：1997年第13卷第2期

页      面：58-64页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 0703[理学-化学] 070301[理学-无机化学] 

主　　题：Synthesis Aromatic DTPA bis(amide) Gadolinium Relaxivity 

摘      要：Five DTPA bis(amide)s have been synthesized and characterized by means of 1 H NMR , FT IR and elemental analyses. The stability constants of their Gd 3+ complexes have been measured using a simple spectrophotometric method. The results show that the complexing properties of the ligands in comparison with those of DTPA are affected by converting two carboxyl groups to amide groups. The relaxation studies have shown that the relaxivity of the chelates is similar to that of Gd DTPA, indicating that in solution all the chelates have one water molecule directly coordinated to the metal ion. Only one water molecule in inner coordination sphere suggests the coordination of the carboxamide oxygen to gadolinium ion, which agrees with the FT IR results.