Nickel-catalyzed kinetic resolution to achieve P-chiral phosphine oxides and sec-phosphine oxides

作     者：Xi Zhang Shao-Qiu Wang Shang-Dong Yang 

作者机构：State Key Laboratory of Applied Organic ChemistryCollege of Chemistry and Chemical EngineeringLanzhou UniversityLanzhou 730000China School of Pharmaceutical ScienceHangzhou Medical CollegeHangzhou 310012China State Key Laboratory for Oxo Synthesis and Selective OxidationLanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000China 

出 版 物：《中国科学:化学英文版》 (SCIENCE CHINA Chemistry)

年 卷 期：2023年第66卷第9期

页      面：2569-2575页

核心收录：

学科分类：07[理学] 070305[理学-高分子化学与物理] 0703[理学-化学] 0702[理学-物理学] 

基　　金：supported by the National Natural Science Foundaiton of China (22171119) Gansu Province Science and Technology Plan for major projects (21ZD4WA021) key research plan (21YF5WA114)。 

主　　题：P-chiral phosphine oxide kinetic resolution Ni catalysis 

摘      要：P-Chiral phosphines and sec-phosphine oxides(SPO) are found in a diverse range of compounds that play crucial roles in various fields, including asymmetric catalysis, materials, agrochemistry, and pharmaceutical chemistry. Herein, we describe an enantioselective Ni-catalyzed kinetic resolution of racemic sec-phosphine oxides to obtain the corresponding optically pure Pchiral phosphine oxides and sec-phosphine oxides, respectively. These products are versatile chiral phosphine building blocks that can be used to construct an extensive range of P-chiral phosphines.