Short-term efficacy analysis and comprehensive evaluation of laparoscopy for patients with rectal cancer-a prospective multi-center study

作     者：Zhixun Zhao Xu Guan Guanyu Yu Yi Feng Qingchao Tang Qian Liu Zhaoxu Zheng Haitao Zhou Jianwei Liang Zheng Jiang Zheng Liu Zheng Lou Haipeng Chen Jiagang Han Yiping Lu Ang Li Xiaohui Du Zhanlong Shen Guole Lin Guiyu Wang Bo Jiang Wei Zhang Xishan Wang 

作者机构：Department of Colorectal SurgeryNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Colorectal SurgeryChanghai HospitalNaval Medical UniversityShanghaiChina Department of Colorectal SurgeryShanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer HospitalChinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical UniversityTaiyuanChina Department of Colorectal SurgeryCenter of CancerThe Second Affiliated Hospital of Harbin Medical UniversityHarbinChina Department of General SurgeryBeijing Chaoyang HosptialCapital Medical UniversityBeijingChina Department of General SurgeryBeijing Hospital of Traditional Chinese MedicineCapital Medical UniversityBeijingChina Department of General SurgeryXuanwu HospitalCapital Medical UniversityBeijingChina Department of General SurgeryFirst Medical Center of ChinesePLA General HospitalBeijingChina Department of Gastroenterological SurgeryPeking University People’s HospitalBeijingChina Department of General SurgeryPeking Union Medical College HospitalPeking Union Medical CollegeChinese Academy of Medical SciencesBeijingChina 

出 版 物：《Holistic Integrative Oncology》 (整合肿瘤学（英文）)

年 卷 期：2023年第2卷第1期

页      面：124-133页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by Beijing Science and Technology Program[D17110002617004] Beijing Hope Run Special Fund of Cancer Foundation of China[LC2019B14 and LC2021A13] 

主　　题：Rectal cancer Laparoscopic surgery Prospective study Minimally invasive surgery Clinical trial 

摘      要：Objective To compare the short-term efficacy indicators of laparoscopic technique and open surgery in patients with rectal cancer surgery,and to further evaluate the safety and efficacy of laparoscopic rectal cancer *** This study adopted a prospective multicenter,open-label,non-randomized concurrent control method to analyze patients who received rectal cancer surgery from 10 colorectal tumor centers across the country from January 2017 to December *** two groups of patients received laparoscopic-assisted surgery and conventional open surgery *** surgeons were selected according to relevant standards and participated in the two groups of operations at the same *** evaluation and analysis of the operation and postoperative recovery,postoperative pathological results,survival information,postoperative related functional scores and other *** In the open surgery group,the proportion of tumors with a maximum diameter of more than 5 cm was higher(χ^(2)=0.089,P=0.018),and the proportion of T4 was higher(χ^(2)=0.478,P0.001).In the laparoscopic group,the proportion of more than 12 harvested lymph nodes was higher(χ^(2)=0.248,P0.001).There were no significant differences in the length of postoperative hospital stay,intraoperative blood loss,time to first flatus after operation,time to first out of bed,time to first liquid diet,and preservation rate of anal sphincter between the two groups,but in the laparoscopic surgery group the operation time was shorter(t=6.750,P0.001)and postoperative pain was less(t=0.896,0.63,0.964,and 0.989 on postoperative days 1,2,and 3,respectively,all P0.001).The incidence of grade 2–4 adverse complication in the two groups was 12.5%and 14.6%,respectively,with no statistical difference(χ2=0.061,P=0.105),but the incidence of incision infection was lower in the laparoscopy group(χ^(2)=0.19,P0.001).There was no significant difference in 3-year disease-free survival between the two group