Polylysine complexes and their biomedical applications
作者机构：Department of Rheumatology and ImmunologyInstitute of Translational MedicineThe Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210008China
出 版 物：《再生工程(英文)》 (Engineered Regeneration)
年 卷 期：2023年第4卷第1期
页 面：20-27页
核心收录：
学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 08[工学]
基 金：supported by the Natural Science Foundation of Jiangsu Province (BK20210016) the National Key R&D Program of China (2020YFA0710800) the Key Program of National Natural Science Foundation of China (grant no.81930043) the Major International (Regional)Joint Research Project of China (grant no.81720108020) the Jiangsu Provincial Key Research and Development Program (BE2020621).
主 题：Polylysine cargo delivery bioadhesive antibacterial biomedicine
摘 要：Poly-L-lysine(PLL)is a water-soluble biopolymer consist of repeating unit of L-lysine.It displays intrinsic non-antigenicity,antibacterial property,biocompatibility,and biodegradability,and facile synthesis procedure,there-fore has attracted particular attention in various biomedical and pharmaceutical applications.Following a brief introduction to PLL synthesis,this review focuses on the significant advances of PLL and PLL-derived complexes utilized in cargo delivery,tissue adhesives,and antibacterial materials.Meanwhile,this review summarized the modification and optimization of PLL complexes for further clinical translational studies.The final section dis-cusses the challenges and opportunities of PLL-based complexes in the biomedical areas.
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