Efficacy and moderating factors of the Early Start Denver Model in Chinese toddlers with autism spectrum disorder:a longitudinal study
作者机构：Child Developmental and Behavioral CenterThe Third Affiliated Hospital of Sun Yat-sen UniversityNo.600Tianhe RoadGuangzhou510630China
出 版 物：《世界儿科杂志:英文版》 (World Journal of Pediatrics)
年 卷 期：2023年第19卷第8期
页 面：741-752页
核心收录：
学科分类：1002[医学-临床医学] 100205[医学-精神病与精神卫生学] 10[医学]
基 金：This study was supported by grants from the Scientific Research project of National Health Commission(No:201302002) National Natural Science Foundation of China(No:81873801) Technology Program of Guangzhou,China(No:201903010040) Science and Technology Program of Guangzhou(202007030011)
主 题：Autism spectrum disorder Efficacy Early Start Denver Model Longitudinal Moderating factors Stereotyped behavior
摘 要：Background Several studies have shown the effectiveness of the Early Start Denver Model(ESDM),but few studies have explored the long-term efficacy of *** study aimed to explore the efficacy and moderating factors of ESDM in Chinese toddlers with autism spectrum disorder(ASD)in a longitudinal *** A total of 60 toddlers with ASD were recruited and randomly divided into two groups:ESDM group all received 24 weeks intervention;Control group were waiting for *** assessment(T0)was conducted before intervention,including Gesell Developmental Scale(GDS)and Psycho-educational Profile-3rd Edition(PEP-3).All toddlers with ASD were examined in the first assessment(T1)at 6 months and in the second assessment(T2)at 12 *** In T1 assessment,the increments in speech and personal communication development quotient in GDS were significantly larger in the ESDM group than in the control group(P=0.010,0.047).In T2 assessment,the ESDM group had higher elevation in cognitive verbal/preverbal(CVP),social reciprocity and characteristic verbal behaviors assessed by PEP-3(P=0.021,0.046,0.014).In addition,the severity of stereotyped behavior was negatively associated with improvement in *** income was positively associated with improvement in speech and CVP(all P0.05).Conclusions ESDM can effectively improve speech and communication in toddlers with ASD after 24-week *** importantly,ESDM can promote cognition and social interaction and can reduce stereotyped verbal behavior in toddlers with ASD in longitudinal *** severity of stereotyped behavior and family ecological factors may be considered as affecting the efficacy of ESDM.
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