Metabolomics in drug discovery: Restoring antibiotic pipeline
作者机构：Department of Pharmaceutical ChemistryPunjab University College of PharmacyUniversity of the PunjabLahorePakistan School of MedicalIndigenous and Health SciencesUniversity of WollongongNew South WalesAustralia Department of General SurgeryLahore General HospitalLahorePakistan Department of Pharmaceutical ChemistryHamza College of PharmacyLahorePakistan
出 版 物：《亚太热带生物医学杂志:英文版》 (Asian Pacific Journal of Tropical Biomedicine)
年 卷 期：2023年第13卷第9期
页 面：378-383页
核心收录：
学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 1002[医学-临床医学] 100602[医学-中西医结合临床] 10[医学]
主 题：Metabolomics Infectious diseases Drug discovery Antibiotics Biomarkers
摘 要：Metabolomics has emerged as a valuable tool in drug discovery and development,providing new insights into the mechanisms of action and toxicity of potential therapeutic *** focuses on the comprehensive analysis of primary as well as secondary metabolites,within biological *** provides a comprehensive understanding of the metabolic changes that occur within microbial pathogens when exposed to therapeutic agents,thus allowing for the identification of unique metabolic targets that can be exploited for therapeutic *** approach can also uncover key metabolic pathways essential for survival,which can serve as potential targets for novel *** analyzing the metabolites produced by diverse microbial communities,metabolomics can guide the discovery of previously unexplored sources of *** review explores some examples that enable medicinal chemists to optimize drug structure,enhancing efficacy and minimizing toxicity via metabolomic approaches.
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