Effects of viral load on tenofovir vs. entecavir efficacy in recurrence prevention of hepatitis B virus-related hepatocellular carcinoma

作     者：Weili Qi Junyi Shen Yu Zhang Fengwei Gao Chuan Li Weili Qi;Junyi Shen;Yu Zhang;Fengwei Gao;Chuan Li

作者机构：China610041 China610041 China610072 China614000 

出 版 物：《中华医学杂志（英文版）》 (Chinese Medical Journal)

年 卷 期：2023年第136卷第19期

页      面：2362-2364页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 100214[医学-肿瘤学] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：This study was supported by grants from the National Natural Science Foundation of China （Nos. 81900576, 82100650） the Science and Technological Supports Project of Sichuan Province （Nos. 2019YJ0149, 22ZDYF1593） as well as the Post-Doctor Research Project, West China Hospital, Sichuan University （No. 2020HXBH069） 

摘      要：Serum hepatitis B virus deoxyribonucleic acid (HBVDNA) load is a critical index used to reflect the degree of viral replication in hepatocytes and to evaluate host hepatitis viral status. The risk of hepatocellular carcinoma (HCC) incidence or recurrence varies depending on whether the HBV-DNA load is high or low. Consistent with previous studies and expert opinion, a HBV-DNA level 2000 IU/mL was defined as a high HBV-DNA load in the current study.