Structural insight into EV-A713A protein and its interaction with a peptide inhibitor
作者机构：Department of Pathogen BiologySchool of Basic MedicineTongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious DiseasesHuazhong University of Science and TechnologyWuhan430030China Medical Subcenter of HUST Analytical&Testing CenterHuazhong University of Science and TechnologyWuhan430030China MOE Key Laboratory for Membraneless Organelles and Cellular DynamicsSchool of Life SciencesDivision of Life Sciences and MedicineUniversity of Science and Technology of Chin1Hefei230027China State Key Laboratory of VirologyWuhan Institute of VirologyChinese Academy of SciencesWuhan430071China Institute of Health Inspection and TestingHubei Provincial Center for Disease Control and Prevention(Hubei CDC)Wuhan430079China Department of PediatricsTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China
出 版 物：《Virologica Sinica》 (中国病毒学（英文版）)
年 卷 期：2023年第38卷第6期
页 面：975-979页
核心收录：
学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学]
基 金：funded by the National Key Research and Development Program of China 国家自然科学基金 the Hubei Provincial Nature Science Foundation the Hubei Provincial Public Health Outstanding Young Talents Project (to Y.L. and K.C.) the Hubei Province Natural Science Foundation for Distinguished Young Scholars the Open Research Fund Program of the State Key Laboratory of Virology of China
主 题：enterovirus insight
摘 要：Dear Editor,Hand,foot,and mouth disease(HFMD)is a common illness among children that is usually mild and ***,in some severe cases,patients may rapidly develop neurological and systemic complications that can be fatal(Ooi et al.,2010).HFMD is caused by a few serotypes of human enterovirus A(HEV-A)species(Yu and Cowling,2019),with enterovirus A71(EV-A71)and coxsackievirus A16(CV-A16)being the most typical causative agents(Yu and Cowling,2019).Furthermore,severe neurological sequelae are more common in cases with EV-A71 serotype infection than other serotypes(Ooi et al.,2010;Yu and Cowling,2019).There has been a significant increase in EV-A71 epidemic activity throughout the Asia–Pacific region(McMinn,2002)since EV-A71 was first isolated from a patient with central nervous system(CNS)disease in 1969(Schmidt et al.,1974).EV-A71 is a small non-enveloped virus belonging to HEV-A species of the genus Enterovirus in the family Picornaviridae(Nasri et al.,2007).Its genome is a single-stranded positive-sense RNA of approximately 7400 bp in length and contains only one complete open reading frame(ORF),which encodes a large polyprotein(Solomon et al.,2010).
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