Bioactivity profile of dissolved organic matter and its relation to molecular composition

作     者：Teresa S.Catalá Linn G.Speidel Arlette Wenzel-Storjohann Thorsten Dittmar Deniz Tasdemir 

作者机构：Global Society InstituteWälderhausHamburgGermany Organization for ScienceEducation and Global Society gGmbHStuttgartGermany ICBM-MPI Bridging Group for Marine GeochemistryInstitute for Chemistry and Biology of the Marine Environment(ICBM)University of OldenburgOldenburgGermany Geological InstituteDepartment of Earth SciencesETH Zurich8092 ZurichSwitzerland GEOMAR Centre for Marine BiotechnologyResearch Unit Marine Natural Products ChemistryGEOMAR Helmholtz Centre for Ocean Research KielAm Kiel-Kanal 4424106 KielGermany Helmholtz Institute for Functional Marine BiodiversityUniversity of OldenburgOldenburgGermany Kiel UniversityChristian-Albrechts-Platz 424118 KielGermany 

出 版 物：《Natural Products and Bioprospecting》 (应用天然产物（英文）)

年 卷 期：2023年第13卷第1期

页      面：425-440页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：Marie Skłodowska-Curie individual Fellowship H2020-MSCA-IF-2016749586 Teresa S.Catalá Carl von Ossietzky Universität Oldenburg 

主　　题：Dissolved organic matter Antibacterial activity Antifungal activity Antioxidant activity Molecular composition 

摘      要：Dissolved organic matter(DOM)occupies a huge and uncharted molecular *** its properties,DOM can be presented as a promising biotechnological ***,research into bioactivities of DOM is still in early *** this study,the biotechnological potential of terrestrial and marine DOM,its molecular composition and their relationships are *** were screened for their in vitro antibacterial,antifungal,anticancer and antioxidant *** activity was detected against Staphylococcus aureus in almost all DOM samples,with freshwater DOM showing the lowest IC50 *** samples also inhibited Staphylococcus epidermidis,and four DOM extracts showed up to fourfold higher potency than the reference *** activity was limited to only porewater DOM towards human dermatophyte Trichophyton *** significant in vitro anticancer activity was *** antioxidant potential was *** molecular characterization by FT-ICR MS allowed a broad compositional *** main distinguished groups have been identified by PCoA *** activities are related to high aromaticity content and highly-unsaturated molecular formulae(O-poor).Antifungal effect is correlated with highly-unsaturated molecular formulae(O-rich).Antioxidant activity is positively related to the presence of double bonds and *** study evidenced for the first time antibacterial and antifungal activity in DOM with potential applications in cosmeceutical,pharmaceutical and aquaculture *** lack of cytotoxicity and the almost unlimited presence of this organic material may open new avenues in future marine bioprospect-ing efforts.