Association of carbon monoxide poisonings and carboxyhemoglobin levels with COVID-19 and clinical severity

作     者：Abuzer Coskun Burak Demirci Kenan Ahmet Turkdogan 

作者机构：Emergency Medicine ClinicIstanbul Bagcilar Training and Research HospitalIstanbul 34200Turkey Emergency Medicine DepartmentIstanbulÇam and Sakura City HospitalIstanbul 34494Turkey 

出 版 物：《World Journal of Methodology》 (世界方法学杂志)

年 卷 期：2023年第13卷第4期

页      面：248-258页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Emergency department Coronavirus disease 2019 Carbon monoxide Mortality Carboxyhemoglobin Intoxication Poisoning 

摘      要：BACKGROUND Coronavirus disease 2019(COVID-19),which recently spread throughout the entire world,is still a significant health ***,the most common cause of risky poisoning in emergency services is carbon monoxide(CO)*** disorders seem to merit more research as they have an impact on all bodily systems via the *** To determine how arterial blood gas and carboxyhemoglobin(COHb)levels affect the clinical and prognostic results of individuals requiring emergency treatment who have both COVID-19 and CO *** Between January 2018 and December 2021,479 CO-poisoning patients participated in this single-center,retrospective *** were primarily divided into two groups for analysis:Pre-pandemic and pandemic ***,the pandemic era was divided into categories based on the presence of COVID-19 and,if present,the clinical severity of the *** hospital information system was used to extract patient demographic,clinical,arterial blood gas,COVID-19 polymerase chain reaction,and other laboratory *** The mean age of the 479 patients was 54.93±11.51 years,and 187(39%)were female.226(47%)patients were in the pandemic group and 143(30%)of them had a history of *** the mean potential of hydrogen(pH)in arterial blood gas of all patients was 7.28±0.15,it was 7.35±0.10 in the pre-pandemic group and 7.05±0.16 in the severe group during the pandemic period(P0.001).COHb was 23.98±4.19%in the outpatients and 45.26%±3.19%in the mortality group(P0.001).Partial arterial oxygen pressure(PaO2)was 89.63±7.62 mmHg in the pre-pandemic group,and 79.50±7.18 mmHg in the severe group during the pandemic period(P0.001).Despite the fact that mortality occurred in 35(7%)of all cases,pandemic cases accounted for 30 of these deaths(85.7%)(P0.001).The association between COHb,troponin,lactate,partial arterial pressure of carbon dioxide,HCO3,calcium,glucose,age,pH,PaO2,potassium,sodium,and base excess levels in the