Biomarkers in sepsis-looking for the Holy Grail or chasing a mirage!
作者机构：Department of Critical Care MedicineHoly Family HospitalDelhi 110025India
出 版 物：《世界重症医学杂志》 (World Journal of Critical Care Medicine)
年 卷 期：2023年第12卷第4期
页 面：188-203页
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
主 题：Sepsis Sepsis biomarkers Procalcitonin Presepsin Omics
摘 要：Sepsis is defined as a life-threatening organ dysfunction caused by the dysregulated host response to *** is a complex syndrome and is characterized by physiologic,pathologic and biochemical abnormalities in response to an *** of sepsis is based on history,physical examination and other investigations(including biomarkers)which may help to increase the certainty of *** have been evaluated in the past for many diseases and have been evaluated for sepsis as *** may find a possible role in diagnosis,prognostication,therapeutic monitoring and anti-microbial stewardship in *** the pathophysiology of sepsis is quite complex and is incompletely understood,a single biomarker that may be robust enough to provide all information has not been found as of ***,many biomarkers have been studied and some of them have applications at the bedside and guide clinical *** evaluated the PubMed database to search for sepsis biomarkers for diagnosis,prognosis and possible role in antibiotic escalation and *** trials,meta-analyses,systematic reviews and randomized controlled trials were *** studied biomarkers such as procalcitonin,Soluble urokinase-type plasminogen activator(Supar),presepsin,soluble triggering receptor expressed on myeloid cells 1,interleukin 6,C-reactive protein,etc.,have been described for their possible applications as biomarkers in septic *** sepsis biomarkers are still an area of active research with newer evidence adding to the knowledge base *** patients presenting with sepsis,early diagnosis and prompt resuscitation and early administration of anti-microbials(preferably within 1 h)and source control are desired *** may help us in the diagnosis,prognosis and therapeutic monitoring of septic *** marker redefining our view on sepsis is yet a mirage that clinicians and researchers continue to chase.
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