Multinucleated giant cells of bladder mucosa are modified telocytes:Diagnostic and immunohistochemistry algorithm and relation to PDL1 expression score

作     者：Milena Gulinac Tsvetelina Velikova Dorian Dikov 

作者机构：General and Clinical PathologyMedical University of PlovdivPlovdiv 4002Bulgaria Medical FacultySofia UniversitySt.Kliment OhridskiSofia 1407Bulgaria PathologyGrand Hospital de l’Este FrancilienJossigny 1000France 

出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)

年 卷 期：2023年第11卷第26期

页      面：6091-6104页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：the European Union-NextGenerationEU through the National Recovery and Resilience Plan of the Republic of Bulgaria No.BG-RRP-2.004-0008 

主　　题：Multinucleated giant cells Telocytes Urothelial bladder carcinoma Immunohistochemical Vimentin Smooth muscle actin Desmin CD34 CD68 p16 Algorithm PD-L1 Chronic inflammation 

摘      要：BACKGROUND Multinucleated giant cells(MGCs)in bladder carcinomas are poorly *** To describe the function,morphogenesis,and origin of mononuclear and MGCs in urothelial carcinoma(UC)of the bladder in Bulgarian and French *** Urothelial bladder carcinomas(n=104)from 2016-2020 were analyzed retrospectively using immunohistochemical(IHC)and histochemical stain *** cells in the bladder stroma were found in 35.6%of cases,more often in *** We confirm that MGCs in the mucosa in UC of the bladder were positive for both mesenchymal and myofibroblast markers(vimentin,smooth muscle actin,Desmin,and CD34)and the macrophage marker ***,IHC studies revealed the following profile of these cells:Positive for p16;negative for epithelial(CK AE1/AE3 and GATA-3),vascular(CD31),neural(PS100 and CKIT),cambial,blastic(CD34-blasts and C-KIT),and immune markers(IG G,immunoglobulin G4,and PD-L1);no proliferative activity,possess no specific immune function,and cannot be used to calculate the Combined Positive Score *** In conclusion,the giant stromal cells in non-tumor and tumor bladder can be used as a characteristic and relatively constant,although nonspecific,histological marker for chronic bladder damage,reflecting the chronic irritation or ***,according to the morphological and IHC of the mono-and multinucleated giant cells in the bladder,they are most likely represent telocytes capable of adapting their morphology to the pathology of the organ.