Heparanase inhibition leads to improvement in patients with acute gastrointestinal injuries induced by sepsis
作者机构：The First Clinical Medical School of Lanzhou UniversityLanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of Emergency Critical Care MedicineThe First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina
出 版 物：《世界胃肠病学杂志:英文版》 (World Journal of Gastroenterology)
年 卷 期：2023年第29卷第35期
页 面：5154-5165页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：the Science and Technology Department of Gansu Province,No.20JR5RA35 Science and Technology Project of Gansu Province,No.22JR10KA009 Talent Innovation and Entrepreneurship Project of Science and Technology Bureau of Chengguan District,Lanzhou,No.2020RCCX0030 Lanzhou Science and Technology Development Guiding Plan Project,No.2019-ZD-37
主 题：Sepsis Acute gastrointestinal injury Heparanase Autophagy
摘 要：BACKGROUND Patients with sepsis are at high risk for acute gastrointestinal injury(AGI),but the diagnosis and treatment of AGI due to sepsis are ***(HPA)plays an important role in septic AGI(S-AGI),but its specific mechanism is not completely understood,and few clinical reports are *** To explore the effect and mechanism of HPA inhibition in S-AGI *** In our prospective clinical trial,48 patients with S-AGI were randomly assigned to a control group to receive conventional treatment,whereas 47 patients were randomly assigned to an intervention group to receive conventional treatment combined with low molecular weight *** grade,sequential organ failure assessment score,acute physiology and chronic health evaluation II score,D-dimer,activated partial thromboplastin time(APTT),anti-Xa factor,interleukin-6,tumour necrosis factor-α,HPA,syndecan-1(SDC-1),LC3B(autophagy marker),intestinal fatty acid binding protein,D-lactate,motilin,gastrin,CD4/CD8,length of intensive care unit(ICU)stay,length of hospital stay and 28-d survival on the 1^(st),3^(rd) and 7^(th) d after treatment were *** between HPA and AGI grading as well as LC3B were *** operator characteristic(ROC)curves were generated to evaluate the diagnostic value of HPA,intestinal fatty acid binding protein and D-lactate in *** Serum HPA and SCD-1 levels were significantly reduced in the intervention group compared with the control group(P0.05).In addition,intestinal fatty acid-binding protein,D-lactate,AGI grade,motilin,and gastrin levels and sequential organ failure assessment score were significantly decreased(P0.05)in the intervention ***,LC3B,APTT,anti-Xa factor,and CD4/CD8 were significantly increased(P0.05)in the intervention *** significant differences in interleukin-6,tumour necrosis factor-α,d-dimer,acute physiology and chronic health evaluation II score,length of ICU stay,length of hospital stay,
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