Establishment and evaluation of animal models of sepsis-associated encephalopathy

作     者：Mubing Qin Yanxia Gao Shigong Guo Xin Lu Qian Zhao Zengzheng Ge Huadong Zhu Yi Li Mubing Qin;Yanxia Gao;Shigong Guo;Xin Lu;Qian Zhao;Zengzheng Ge;Huadong Zhu;Yi Li

作者机构：Emergency DepartmentState Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalPeking Union Medical CollegeChinese Academy of Medical SciencesBeijing 100730China Emergency Departmentthe First Affi liated Hospital of Zhengzhou UniversityZhengzhou 450052China Department of Rehabilitation MedicineSouthmead HospitalSouthmead RoadBristol BS105NBUK Health Service Department of the Guard Bureau of the Joint Staff DepartmentBeijing 100017China 

出 版 物：《World Journal of Emergency Medicine》 (世界急诊医学杂志（英文）)

年 卷 期：2023年第14卷第5期

页      面：349-353页

核心收录：

学科分类：100218[医学-急诊医学] 1002[医学-临床医学] 10[医学] 

基　　金：supported by the National High Level Hospital Clinical Research Fund (2022-PUMCH-B-109) CAMS Innovation Fund for Medical Sciences (CIFMS)(2021-1-I2M-020)。 

主　　题：Sepsis Sepsis-associated encephalopathy Animal model Systematic review 

摘      要：BACKGROUND:Sepsis-associated encephalopathy(SAE) is a critical disease caused by sepsis.In addition to high mortality,SAE can also adversely aff ect life quality and lead to significant socioeconomic costs.This review aims to explore the development of evaluation animal models of SAE,giving insight into the direction of future research in terms of its pathophysiology and therapy.METHODS:We performed a literature search from January 1,2000,to December 31,2022,in MEDLINE,PubMed,EMBASE,and Web of Science using related keywords.Two independent researchers screened all the accessible articles based on the inclusion and exclusion criteria and collected the relevant data of the studies.RESULTS:The animal models for sepsis are commonly induced through cecal ligation and puncture(CLP) or lipopolysaccharide(LPS) injection.SAE can be evaluated using nervous reflex scores and sepsis evaluation during the acute phase,or through Morris water maze(MWM),openfield test,fear condition(FC) test,inhibitory avoidance,and other tests during the late phase.CONCLUSION:CLP and LPS injection are the most common methods for establishing SAE animal models.Nervous reflexs cores,MWM,FC test,and inhibitory avoidance are widely used in SAE model analysis.Future research should focus on establishing a standardized system for SAE development and analysis.