Intelligent tunable CAR-T cell therapy leads the new trend
作者机构：Shanghai Frontiers Science Center of Genome Editing and Cell TherapyShanghai Key Laboratory of Regulatory BiologyInstitute of Biomedical Sciences and School of Life SciencesEast China Normal UniversityShanghaiChina
出 版 物：《Synthetic and Systems Biotechnology》 (合成和系统生物技术（英文）)
年 卷 期：2023年第8卷第4期
页 面：606-609页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：supported by the National Key R&D Program of China(2019YFA0802802) the National Natural Science Foundation of China(81772622)
主 题：Chimeric antigen receptor T Tumor Safety and efficacy On and off systems Autologous universal system Synthetic notch system
摘 要：Adoptive transfer of T cells engineered with chimeric antigen receptor(CAR)has been proved to have robust anti-tumor effects against hematological ***,problems about safety and efficacy,such as cytokine release syndrome(CRS),T cell exhaustion and antigen escape are still raised when patients are treated with CAR-T ***,CAR-T therapy has limited applications in treating solid tumors,owing to inefficient infiltration and poor functional persistence of CAR-T cells and diverse immunosuppression in tumor *** order to overcome these limitations and broad its applications,multiple controllable CAR-T technologies were *** this article,we review the designs of intelligent controlled CAR-T technologies and the innovations that they bring about in recent years.
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