Elevated level of high-sensitivity cardiac troponin I as a predictor of adverse cardiovascular events in patients with heart failure with preserved ejection fraction

作     者：Hongyu Hu Jingjin Li Xin Wei Jia Zhang Jiayu Wang 

作者机构：Department of CardiovascularBeijing Tiantan HospitalCapital Medical UniversityBeijing 100070China Department of NeurologyBeijing Tiantan HospitalCapital Medical UniversityBeijing 100070China Department of NeurocardiologyBeijing Tiantan HospitalCapital Medical UniversityBeijing 100070China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2023年第136卷第18期

页      面：2195-2202页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Heart failure with preserved ejection fraction High-sensitivity cardiac troponin I Cardiogenic mortality Heart failure hospitalization 

摘      要：Background:The relationship between the elevation of cardiac troponin and the increase of mortality and hospitalization rate in patients with heart failure with reduced ejection fraction is *** study investigated the association between the extent of elevated levels of high-sensitivity cardiac troponin I(hs-cTnI)and the prognosis in heart failure with preserved ejection fraction ***:A retrospective cohort study consecutively enrolled 470 patients with heart failure with preserved ejection fraction from September 2014 to August *** to the level of hs-cTnI,the patients were divided into the elevated level group(hs-cTnI0.034 ng/mL in male and hs-cTnI0.016 ng/mL in female)and the normal level *** of the patients were followed up once every 6 *** cardiovascular events were cardiogenic death and heart failure ***:The mean follow-up period was 36.2±7.9 *** mortality(18.6%[26/140]vs.1.5%[5/330],P0.001)and heart failure(HF)hospitalization rate(74.3%[104/140]vs.43.6%[144/330],P0.001)were significantly higher in the elevated level *** Cox regression analysis showed that the elevated level of hs-cTnI was a predictor of cardiogenic death(hazard ratio[HR]:5.578,95%confidence interval[CI]:2.995-10.386,P0.001)and HF hospitalization(HR:3.254,95%CI:2.698-3.923,P0.001).The receiver operating characteristic curve demonstrated that a sensitivity of 72.6%and specificity of 88.8%for correct prediction of adverse cardiovascular events when a level of hs-cTnI of 0.1305 ng/mL in male and a sensitivity of 70.6%and specificity of 90.2%when a level of hs-cTnI of 0.0755 ng/mL in female were used as the cut-off ***:Significant elevation of hs-cTnI(≥0.1305 ng/mL in male and≥0.0755 ng/mL in female)is an effective indicator of the increased risk of cardiogenic death and HF hospitalization in heart failure with preserved ejection fraction patients.