Predicting eczema severity beyond childhood

作     者：Kam Lun Hon Yin-Ching K.Tsang Terence Chuen W.Poon Nga Hin Pong Matthew Kwan Shirley Lau Yuen-Chun Chiu Hin-Hei Wong Ting-Fan Leung 

作者机构：Department of PediatricsThe Chinese University of Hong KongPrince of Wales HospitalHong KongChina Faculty of MedicineThe Chinese University of Hong KongChina 

出 版 物：《世界儿科杂志:英文版》 (World Journal of Pediatrics)

年 卷 期：2016年第12卷第1期

页      面：44-48页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：atopic dermatitis atopy eczema Nottingham Eczema Severity Score prognosis 

摘      要：Background:We evaluated factors associated with eczema severity in adolescence.Methods:Nottingham Eczema Severity Score(NESS),family and personal history of atopy,skin prick test for common food and aeroallergens,highest serum IgE level and eosinophil count were evaluated.Patients with paired NESSs(childhood-NESS is NESS performed at10 years)were further analyzed.Results:Adolescence-NESS(n=383 patients)was associated with eczema onset in infancy,dust mite and food allergen sensitization,dietary avoidance,use of wet wrap,traditional Chinese medicine,immunomodulant(azathioprine or cyclosporine),high IgE level,eosinophil count,but not with family/personal history of atopy.Eighty-two patients had both childhood-NESS and adolescence-NESS(mean follow-up of 6.8 years)showing that adolescence-NESS was associated with childhood-NESS severity grades(P=0.034).Of these patients,48%remained in the same severity grades,whereas 39%improved,and 13%deteriorated from childhood to adolescence.Conclusions:It is not possible to assure parents that their child can outgrow eczema.In eczema prognosis research,long-term follow-up is warranted.