Phosphorylation-driven aggregative proteins in neurodegenerative diseases:implications and therapeutics

作     者：Alba Espargaró Raimon Sabate Alba Espargaró;Raimon Sabate

作者机构：Department of Pharmacy and Pharmaceutical Technology and Physical-ChemistrySchool of PharmacyUniversity of BarcelonaBarcelonaSpain Institute of Nanoscience and Nanotechnology(IN2UB)University of BarcelonaBarcelonaSpain 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2024年第19卷第5期

页      面：966-968页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100204[医学-神经病学] 10[医学] 

基　　金：funded by Ministerio de Ciencia e Innovación Grant Number PID2021-127863OB-I00(to AE and RS) 

主　　题：tau Aβ Alzheimer 

摘      要：Protein aggregation is related to a large number of neurodegenerative *** in some cases,aggregation is induced by hyperphosphorylation of a given *** is the case of tau,TAR DNA-binding protein 43(TDP-43),amyloid-beta peptides(Aβ)and alpha-synuclein(α-syn),which play a key pathogenic role in Alzheimer’s disease(AD),Parkinson’s disease(PD)and amyotrophic lateral sclerosis,among others(Tenreiro et al.,2014;Chiti and Dobson,2017).In this perspective,we will discuss both the relationship between phosphorylation and amyloid aggregation as well as current and future therapeutic strategies aimed at inhibiting specific kinases involved in the phosphorylation step or inhibiting subsequent protein aggregation.