Oxidation of Difluorocarbene by Pyridine N-Oxide and Ensuing Access to Carbamoyl Fluorides

作     者：Hai-Jun Tang Xue-Min Shi Xiao-Yu Zhu Cheng-Qiang Wang Chao Feng Hai-Jun Tang;Xue-Min Shi;Xiao-Yu Zhu;Cheng-Qiang Wang;Chao Feng

作者机构：Technical Institute of Fluorochemistry(TiF)Institute of Advanced Synthesis(iAs)State Key Laboratory of Material-Oriented Chemical EngineeringSchool of Chemistry and Moiecular EngineeringNanjing TechUniversity30 South Puzhu RoadNanjingJiangsu211816China 

出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)

年 卷 期：2023年第41卷第22期

页      面：2981-2987页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：The authors gratefully acknowledge the financial support from the National Natural Science Foundation of China(grant no.22271151)and the Distinguished Youth Foundation of Jiangsu Province 

主　　题：Difluorocarbene Pyridine N-oxide Fluorophosgene Carbamoyl fluorides Amines Fluorine 

摘      要：A practical one-pot preparation of carbamoyl fluorides from easily obtained pyridine N-oxide,commercially available secondary amines and synthetically versatile difluorocarbene precursors(Ruppert-Prakash reagent or Chen s reagent)was developed herein,which dexterously resorted to the oxidation of difluorocarbene by external pyridine N-oxide to produce the toxic and gaseous fluorophosgene in *** features of this method include nice functionality tolerance,late-stage modification of drug molecules and the recoveryand recycle of quinoline.