Difluoroalkylation/Lactonization of Alkenes with BrCF_(2)CO_(2)K via Photoredox Catalysis:Access toα,α-Difluoro-γ-lactones
作者机构：Key Laboratory of Organofluorine ChemistryShanghai Institute of Organic ChemistryUniversity of Chinese Academy of SciencesChinese Academy of Sciences345 Lingling RoadShanghai200032 China Department of ChemistryInnovative Drug Research CenterShanghai UniversityShanghai200444 China
出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)
年 卷 期：2023年第41卷第21期
页 面：2819-2824页
核心收录：
学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学]
基 金：We thank the National Key Research and Development Program of China(2021YFF0701700) the National Natural Science Foundation of China(21971252,21991122,22271181) the Science and Technology Commission of Shanghai Municipality(22ZR1423600)for financial support
主 题：Photoredox Catalysis Fluorine Lactones Alkenes
摘 要：Due to its unique electronic properties,the difluoromethylene group(CF2)has served as a valuable unity in the design of biologically active ***γ-lactones display a broad range of biological properties,α,α-difluoro-γ-lactones may exhibit unexpected biological activities,and thus their synthesis has received increasing *** synthetic methods suffer from tedious multi-step processes,and very few effective methods have been reported ***,we describe the difunctionalization of alkenes with BrCF_(2)CO_(2)K under photoredox catalysis with the use of a boron-Lewis acid for the access toα,α-difluoro-γ-*** this transformation,the alkene substrates and the used reagents,including BrCF_(2)CO_(2)K and the boron-Lewis acid,PhB(OH)2 or BF3·THF,are cheap and widely *** efficiency and atom economy may make this protocol attractive.
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