A common variant in AAK1 reduces risk of noise-induced hearing loss

作     者：Qixuan Wang Xueling Wang Tao Yang Lu Yang Huihui Liu Yihang Zheng Guixian Jiang Hongchao Liu Chenhui Huang Juan Chen Zhentao Wang Zhaoyan Wang Wei Zhao Jiannan Lin Xuejie Zhang Junbo Shi Kun Han Xingyu Le Yan Ren Yun Li Yingying Hong Wentao Shi Dongqi Cui Minfei Qian Jun Xu Xiaofei Zheng Yunge Gao Chen Li James Lin Zhiwu Huang Hao Wu Qixuan Wang;Xueling Wang;Tao Yang;Lu Yang;Huihui Liu;Yihang Zheng;Guixian Jiang;Hongchao Liu;Chenhui Huang;Juan Chen;Zhentao Wang;Zhaoyan Wang;Wei Zhao;Jiannan Lin;Xuejie Zhang;Junbo Shi;Kun Han;Xingyu Le;Yan Ren;Yun Li;Yingying Hong;Wentao Shi;Dongqi Cui;Minfei Qian;Jun Xu;Xiaofei Zheng;Yunge Gao;Chen Li;James Lin;Zhiwu Huang;Hao Wu

作者机构：Department of Otolaryngology-Head and Neck Surgery Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Ear Institute Shanghai Jiao Tong University School of Medicine Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases Biobank Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai Institute of Precision Medicine Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine The Core Laboratory in the Medical Center of Clinical Research Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Clinical Research Center Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Network and Information Center Shanghai Jiao Tong University College of Health Science and Technology Shanghai Jiao Tong University School of Medicine 

出 版 物：《National Science Review》 (国家科学评论(英文版))

年 卷 期：2023年第10卷第7期

页      面：77-80页

核心收录：

学科分类：1002[医学-临床医学] 100213[医学-耳鼻咽喉科学] 10[医学] 

基　　金：supported by the National Key R&D Program of China (2017YFC1001804 to H.W.) the Shanghai Science and Technology Committee (21JC1404000 to H.W.) the Shanghai Key Clinical Specialty Construction Project(SHSLCZDZK00802 to H.W.) the Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases (14DZ2260300 to H.W.) the Medical Engineering Cross Research Funding of Shanghai Jiao Tong University (YG2021ZD14 to Z.H.) 

摘      要：Noise-induced hearing loss (NIHL) is one of the most common types of hearing loss and contributes to significant morbidity worldwide,as well as being the major cause of age-related hearing loss and *** World Health Organization (WHO) estimates that 10%of the world’s population is exposed to sound levels that could potentially cause NIHL[1].It has been widely accepted that NIHL is a multifactorial genetic disorder with estimated heritability of 36%to 40%[2].Ideally,identification of the modifying genetic variants would help protect individuals at high risk of *** decades,many geneticists have searched for genes that either predispose or protect from *** r,the majority of genetic studies for NIHL were conducted in independent known candidate genes [3].