On the sampling strategies and models for measuring diffusion exchange with a double diffusion encoding sequence

作     者：Alfredo Ordinola Shan Cai Peter Lundberg Ruiliang Bai Evren Ozarslan Alfredo Ordinola;Shan Cai;Peter Lundberg;Ruiliang Bai;Evren Özarslan

作者机构：Department of Biomedical Engineering(IMT)Link oping UniversityLink opingS-58185Sweden Department of Radiation PhysicsDepartment of HealthMedicine and Caring Sciences(HMV)Link oping UniversityLink opingS-58183Sweden Center for Medical Image Science and Visualization(CMIV)Link oping UniversityLink opingS-58185Sweden School of MedicineZhejiang University866 Yuhangtang RdHangzhou310058China 

出 版 物：《Magnetic Resonance Letters》 (磁共振快报（英文）)

年 卷 期：2023年第3卷第3期

页      面：232-247,I0003页

核心收录：

学科分类：07[理学] 0701[理学-数学] 070101[理学-基础数学] 

基　　金：the Swedish Foundation for International Cooperation in Research and Higher Education(STINT) and the Swedish Research Council(Dnr 2022e04715) 

主　　题：Diffusion MRI Water exchange Sampling schemes Double diffusion encoding 

摘      要：Water exchange between the different compartments of a heterogeneous specimen can be characterized via diffusion magnetic resonance imaging(dMRI).Many analysis frameworks using dMRI data have been proposed to describe exchange,often using a double diffusion encoding(DDE)stimulated echo *** such as diffusion exchange weighted imaging(DEWI)and the filter exchange and rapid exchange models,use a specific subset of the full space DDE *** this work,a general representation of the DDE signal was employed with different sampling schemes(namely constant b1,diagonal and anti-diagonal)from the data reduction models to estimate exchange.A near-uniform sampling scheme was proposed and compared with the other sampling *** filter exchange and rapid exchange models were also applied to estimate exchange with their own subsampling *** subsampling schemes and models were compared on both simulated data and experimental data acquired with a benchtop MR *** synthetic data,the diagonal and near-uniform sampling schemes performed the best due to the consistency of their estimates with the ground *** experimental data,the shifted diagonal and near-uniform sampling schemes outperformed the others,yielding the most consistent estimates with the full space *** results suggest the feasibility of measuring exchange using a general representation of the DDE signal along with variable sampling *** future studies,algorithms could be further developed for the optimization of sampling schemes,as well as incorporating additional properties,such as geometry and diffusion anisotropy,into exchange frameworks.