A Direct Route to Tetrahydropyridazine Derivatives via DMAP-Catalyzed [4+2] Annulation of Allenoates with Arylazosulfones

作     者：Xin Ji Ziyang Li Jinfeng Zhang Yicheng Zhang Ling-Guo Meng Xin Ji;Ziyang Li;Jinfeng Zhang;Yicheng Zhang;Ling-Guo Meng

作者机构：Key Laboratory of Green and Precise Synthetic Chemistry and ApplicationsMinistry of EducationSchool of Chemistry and Materials ScienceHuaibei Normal UniversityHuaibeiAnhui 235000China 

出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)

年 卷 期：2023年第41卷第22期

页      面：3031-3036,I0002页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：the Independent Research Foundation of Key Laboratory of Green and Precise Synthetic Chemistry and Applications in Huaibei Normal University,Ministry of Education the University Top Talents Academic Funding Project of Anhui Province(gxbjzD2021097) the Natural Science Foundation of Educational Committee from Anhui Province and Huaibei Normal University(KJ2020A0045,KJ2020A1199,KJ2020B01,2023ZK078,2023ZK079) the University Synergy Innovation Program of Anhui Province(GXXT-2020-078)for financial support of this work 

主　　题：DMAP [4+2]Cycloaddition Tetrahydropyridazihe derivatives Pyridazin-3-one derivatives Allenes Zwitterions N-Heterocycles 

摘      要：Herein,a DMAP-catalyzed[4+2]annulation ofα-substituted allenoates with arylazosulfones is reported,which affords facile access to tetrahydropyridazine derivative in synthetically useful *** reaction features mild conditions and good functional group ***,the resultant products can be readily transformed into pyridazin-3-one derivatives in the presence of DDQ.