Superiority of indocyanine green-enhanced near-infrared fluorescence-guided imaging for laparoscopic lymph node dissection in patients with early-stage endometrial cancer: A retrospective cohort study

作     者：Wenzhi Xu Jianqiong Li Saihua Chen Jiaren Zhang Xueyuan Chen Jianhua Yang Wenzhi Xu;lianqiong Li;Saihua Chen;Jiaren Zhang;Xueyuan Chen;Jianhua Yang

作者机构：Department of Obstetrics and GynecologySir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016China Key Laboratory of Reproductive Dysfunction Management of Zhejiang ProvinceZhejiang University School of MedicineHangzhou 310016China Department of Obstetrics and GynecologyTiantai People's HospitalTaizhou 317200China Department of Obstetrics and GynecologyTraditional Chinese Medical Hospital of YongkangYongkang 321300China 

出 版 物：《Laparoscopic, Endoscopic and Robotic Surgery》 (腔镜、内镜与机器人外科（英文）)

年 卷 期：2023年第6卷第3期

页      面：103-108页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the Medical and Health Research Project of Zhejiang Province(2018RC008,2018KY113,and WKJ-ZJ-2125) Zhejiang Provincial Natural Science Foundation(LQ20H040011) 

主　　题：Endometrial cancer Laparoscopic surgery Lymphadenectomy Indocyanine green Near-infrared fluorescence 

摘      要：Objective:Laparoscopic pelvic lymph node dissection(LPND),which is an effective therapy for endometrial cancer,is challenging because of the complexity of the procedure and the occurrence of postoperative *** study aimed to explore whether indocyanine green(ICG)-enhanced nearinfrared(NIR)fluorescence-guided LPND is superior to LPND in the context of early-stage endometrial ***:In this retrospective study,we included the medical records of 190 patients with early-stage endometrioid adenocarcinoma who underwent LPND at the Department of Obstetrics and Gynecology,Sir Run Run Shaw Hospital,Zhejiang University School of Medicine between January 2019 and January *** on whether ICG-enhanced NIR fluorescence guidance was used,the patients were assigned to the ICG group or non-ICG *** were followed-up for one year after *** on demographic characteristics,pathological results,operative outcomes,and complications were collected and ***:The baseline characteristics were comparable between the ICG group and non-ICG group,including age,BMI,pregnancy history,and preoperative *** surgical outcomes,the patients in ICG group had significantly lower intraoperative blood loss(50 mL vs.120 mL,p0.001),less postoperative pelvic drainage time(4.14±1.44 d vs.5.70±1.89 d,p¼0.001),shorter duration of hospital stay(5.26±1.41 d vs.7.37±1.85 d,p¼0.003),higher number of positive pelvic lymph nodes(PLNs)(1 vs.0,p¼0.003),and more PLN-positive cases(16.0%vs.3.6%,p¼0.003)than the patients in non-ICG ***,no significant differences were noted in blood transfusion requirement,operative time,hemoglobin level decreases,number of PLNs harvested,or the presence of lymphocysts between the two ***:Our study showed that ICG-enhanced NIR fluorescence-guided operation may improve the accuracy and safety of LPND.