Joint Detection of Serum Vitamin D,Body Mass Index,and Tumor Necrosis Factor Alpha for the Diagnosis of Crohn’s Disease

作     者：Ying ZHENG Jing-hong LI Shan-ying LIAO Yi-ming FU Yan-jun ZHANG Jun-long LIN Xin-bin CHEN Wei-hong SHA Shi-xue DAI Wen-jun MA Ying ZHENG;Jing-hong LI;Shan-ying LIAO;Yi-ming FU;Yan-jun ZHANG;Jun-long LIN;Xin-bin CHEN;Wei-hong SHA;Shi-xue DAI;Wen-jun MA

作者机构：Department of NutritionGuangdong Provincial People's HospitalGuangdong Academy of Medical SciencesSouthern Medical UniversityGuangzhou510080China The Second School of Clinical MedicineSouthern Medical UniversityGuangzhou 510080China Department of GastroenterologyGuangdong Provincial People's HospitalGuangdong Academy of Medical SciencesSouthern Medical UniversityGuangzhou 510080China The First School of Clinical Medicine&Nanfang HospitalSouthern Medical UniversityGuangzhou 510080China Department of GastroenterologyGuangdong Provincial Geriatrics InstituteNational Key Clinical SpecialtyGuangdong Provincial People's HospitalGuangdong Academy of Medical SciencesSouthern Medical UniversityGuangzhou 510080China 

出 版 物：《当代医学科学(英文)》 (Current Medical Science)

年 卷 期：2023年第43卷第3期

页      面：496-504页

核心收录：

学科分类：1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：This research was funded by Guangzhou Science and Technology Plan Projects(No.202002020066) the Young Scientists to the NSFC Application of Guangdong Provincial People’s Hospital(No.8210120306) the Open Foundation of the State Key Laboratory of Bioactive Seaweed Substance(No.SKL-BMSG2022-03) 

主　　题：Crohn’s disease vitamin D body mass index tumor necrosis factor alpha 

摘      要：Objective Vitamin D(VD)deficiency was reported to contribute to the progression of Crohn’s disease(CD)and affect the prognosis of CD *** study investigated the role of serum VD,body mass index(BMI),and tumor necrosis factor alpha(TNF-α)in the diagnosis of Crohn’s *** CD patients(n=76)and healthy subjects(n=76)were enrolled between May 2019 and December *** serum 25-hydroxyvitamin D[25(OH)D]levels,BMI,and TNF-αlevels,together with other biochemical parameters,were assessed before *** diagnostic efficacy of the single and joint detection of serum 25(OH)D,BMI,and TNF-αwas determined using receiver operating characteristic(ROC)*** The levels of 25(OH)D,BMI,and nutritional indicators,including hemoglobin,total protein,albumin,and high-density lipoprotein cholesterol,were much lower,and the TNF-αlevels were much higher in the CD patients than in the healthy subjects(P0.05 for all).The areas under the ROC curve for the single detection of 25(OH)D,BMI,and TNF-αwere 0.887,0.896,and 0.838,respectively,with the optimal cutoff values being 20.64 ng/mL,19.77 kg/m^(2),and 6.85 fmol/mL,*** diagnostic efficacy of the joint detection of 25(OH)D,BMI,and TNF-αwas the highest,with an area under the ROC curve of 0.988(95%CI:0.968–1.000).Conclusion The joint detection of 25(OH)D,TNF-α,and BMI showed high sensitivity,specificity,and accuracy in CD diagnosis;thus,it would be effective for the diagnosis of CD in clinical practice.