The chemokines CXCL8 and CXCL12:molecular and functional properties,role in disease and efforts towards pharmacological intervention
作者机构：Laboratory of Molecular ImmunologyRega InstituteDepartment of MicrobiologyImmunology and TransplantationKU LeuvenLeuvenBelgium
出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)
年 卷 期：2023年第20卷第3期
页 面：217-251页
核心收录：
学科分类：1001[医学-基础医学(可授医学、理学学位)] 100102[医学-免疫学] 10[医学]
基 金：KU Leuven(C1 grant C16/17/010),FWO-Vlaanderen(grant GOF8822N) the Rega Foundation.SC received a PhD fellowship from FWO-Vlaanderen(grant number 11A4220N).Figures 2-5 are created with BioRender.com
主 题：CXCL8 CXCL12 atypical chemokine receptor GPCR glycosaminoglycan
摘 要：Chemokines are an indispensable component of our immune system through the regulation of directional migration and activation of ***8 is the most potent human neutrophil-attracting chemokine and plays crucial roles in the response to infection and tissue ***8 activity inherently depends on interaction with the human CXC chemokine receptors CXCR1 and CXCR2,the atypical chemokine receptor ACKR1,and ***,(hetero)dimerization and tight regulation of transcription and translation,as well as post-translational modifications further fine-tune the spatial and temporal activity of CXCL8 in the context of inflammatory diseases and *** CxCL8 interaction with receptors and glycosaminoglycans is therefore a promising target for therapy,as illustrated by multiple ongoing clinical ***8-mediated neutrophil mobilization to blood is directly opposed by CXCL12,which retains leukocytes in bone ***12 is primarily a homeostatic chemokine that induces migration and activation of hematopoietic progenitor cells,endothelial cells,and several leukocytes through interaction with CXCR4,ACKR1,and ***,it is an essential player in the regulation of embryogenesis,hematopoiesis,and ***,CXCL12 can also exert inflammatory functions,as illustrated by its pivotal role in a growing list of pathologies and its synergy with CXCL8 and other chemokines to induce leukocyte ***,we review the plethora of information on the CXCL8 structure,interaction with receptors and glycosaminoglycans,different levels of activity regulation,role in homeostasis and disease,and therapeutic ***,we discuss recent research on CXCL12 biochemistry and biology and its role in pathology and pharmacology.
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