Profound neutralization evasion and augmented host cell entry are hallmarks of the fast-spreading SARS-CoV-2 lineage XBB.1.5

作     者：Markus Hoffmann Prerna Arora Inga Nehlmeier Amy Kempf Anne Cossmann Sebastian R.Schulz Gema Morillas Ramos Luis A.Manthey Hans-Martin Jäck Georg M.N.Behrens Stefan Pöhlmann 

作者机构：Infection Biology UnitGerman Primate CenterKellnerweg 437077 GöttingenGermany Faculty of Biology and PsychologyGeorg-August-University GöttingenWilhelmsplatz 137073 GöttingenGermany Department for Rheumatology and ImmunologyHannover Medical SchoolCarl-Neuberg-Straße 130625 HannoverGermany Division of Molecular ImmunologyDepartment of Internal Medicine 3Friedrich-Alexander University of Erlangen-NürnbergGlückstraße 691054 ErlangenGermany German Centre for Infection Research(DZIF)partner site Hannover-BraunschweigCarl-Neuberg-Straße 130625 HannoverGermany Centre for Individualized Infection Medicine(CiiM)FeodorLynen-Straße730625 HannoverGermany 

出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)

年 卷 期：2023年第20卷第4期

页      面：419-422页

核心收录：

学科分类：1001[医学-基础医学(可授医学、理学学位)] 100102[医学-免疫学] 10[医学] 

基　　金：BMBF(01KI2006D,01KI20328A,01KX2021) the Ministry for Science and Culture of Lower Saxony(14-76103-184,COFONI Network,including projects 7FF22,6FF22,10FF22) EU(project UNDINE)and the German Research Foundation(DFG PO 716/11-1,PO 716/14-1) H.-M.J.received funding from BMBF(01KI2043,NaFoUniMedCovid19-COVIM:01KX2021) Bavarian State Ministry for Science and the Arts(Bayerisches Staatsministerium für Wissenschaft und Kunst) DFG through the research training groups RTG1660 and TRR130,the Bayerische Forschungsstiftung(Project CORAd) the Kastner Foundation.G.M.N.B.acknowledges funding by the German Center for Infection Research(Deutsches Zentrum für Infektionsforschung,DZIF grant no 80018019238) a European Regional Development Fund(Defeat Corona,ZW7-8515131). 

主　　题：becoming likely lineage 

摘      要：Since late 2022, the share of infections caused by the SARS-CoV2 lineage XBB.1.5 has gradually increased in the United States,resulting in XBB.1.5 becoming the dominating SARS-CoV-2lineage in the United States and a similar trend is likely to soontake place also in European countries. However, information onthe virological properties of XBB.1.5 is scarce. Here, weconducted an initial virological assessment of the SARS-CoV-2XBB.1.5 lineage.