IRF7 and CTSS are pivotal for cutaneous wound healing and may serve as therapeutic targets
作者机构：Department of DermatologyThe First Hospital of China Medical UniversityShenyangChina Key Laboratory of ImmunodermatologyMinistry of Education and NHCNational joint Engineering Research Center for Theranostics of Immunological Skin DiseasesShenyangChina Department of OtolaryngologyHead and Neck SurgeryYantai Yuhuangding HospitalQingdao UniversityYantaiChina Key Laboratory of Health Ministry for Congenital MalformationShengjing HospitalChina Medical UniversityShenyangChina College of Medicine and Biological Information EngineeringNortheastern UniversityNO.3-11Wenhua RoadHeping DistrictShenyangChina
出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)
年 卷 期：2023年第8卷第9期
页 面：3927-3930页
核心收录：
学科分类：1002[医学-临床医学] 100206[医学-皮肤病与性病学] 10[医学]
基 金：This work was funded by Joint grant of Liaoning-NSF(U1908206) National Natural Science Foundation of China(81972940,82171649) National Key Research and Development Program(2021YFC2701003,2021YFC2701104).We acknowledge Dr.Dan Liu,Dr.Yiwen He,and Dr.Shanshan Jia who took part in key experiments concerning ChIP,luciferase reporter assay during revising this study
主 题：healing wound inflammation
摘 要：Dear Editor,Adult cutaneous wounds typically result in deficient regenera-tion due to abnormal fibro-proliferative responses.1 The scarring,while conducive to preventing extended infection and loss of nutrients at the injury site,can be troublesome.2 In contrast,wound healing in embryos showes lower levels of inflammation and a remarkable capacity for remodeling.3 Interestingly,the capability of fetal scarless healing is *** contrasted with the near-normal healing after the injury that occurs in the early gestational period(embryonic day 16,E16),wound healing in late gestation(embryonic day 18,E18)has prominent *** mechanisms responsible for this transition are largely unknown.
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