Endogenous mucin conveyed to the mucosa with microbes can assure lumen fermentation and large intestinal security-swine versus fowl

作     者：Edwin T.Moran Michael R.Bedford Edwin T.Moran;Michael R.Bedford

作者机构：Poultry Science DepartmentAuburn UniversityAL 36849-5416USA AB VistaWoodstock CourtBlenheim RoadMarlborough RoadWiltshireSN84NAUK 

出 版 物：《Animal Nutrition》 (动物营养（英文版）)

年 卷 期：2023年第14卷第3期

页      面：403-410页

核心收录：

学科分类：090502[农学-动物营养与饲料科学] 0905[农学-畜牧学] 09[农学] 

主　　题：Endogenous protein Enterocyte Goblet cell Mucin Large intestine 

摘      要：Endogenous protein leaving the ileum largely consists of accrued mucins from the upper gastrointestinal tract(GIT)that had resisted *** amounts released rely on their mucosal generation during enteral feeding which vary with age as well as *** digestion resistant proteins of endogenous origin continue to be unavailable in the large intestine,whereas those of dietary origin provide amino acids that largely support the existing microbial population while denying limited amounts for *** mucins pre-exist within the large intestine as two layers at the lumen surface.A loose layer harboring a diverse microbial population is superimposed on the unstirred water layer(USWL)which simultaneously acts as an obstacle to microbes at the loose layer while performing as a molecular sieve for *** USWL is formed through interplay between enterocyte and goblet cells;however,the basis for presence of the loose layer is *** intestinal fermentation predominates within the colon of swine,whereas fowl employ their *** within the colon of swine segregates fine materials into haustrae out-pocketings that parallel their placement within the ceca of *** mucins from small intestinal endogenous losses may envelop microbes within the large intestinal lumen to present successive adherents on the USWL that assemble its loose *** loose layer continually functions as a microbial reservoir in support of lumen *** catabolism of mucin within the loose layer is known to be slow,but its proximity to the enterocyte is of advantage to enterocyte absorption with by-product amino acids fostering the USWL.