Efficacy of catgut embedding in Baihui(GV20)and Feishu(BL13)and Pishu(BL20)on lung tissue,brain tissue and blood related indexes in rats with allergic rhinitis of lung deficiency type

作     者：HUANG Heyin WANG Yichen ZHANG Qinxiu WU Xiaojuan WANG Jiang Li Xiangyu PANG Rui FAN Li CAO Liu TANG Luo HUANG Heyin;WANG Yichen;ZHANG Qinxiu;WU Xiaojuan;WANG Jiang;Li Xiangyu;PANG Rui;FAN Li;CAO Liu;TANG Luo

作者机构：Department of ENTSichuan Integrative Medicine HospitalChengdu 610041China Department of orthopaedicsSichuan Province Orthopaedic HospitalChengdu 610000China Department of ENTAffiliated Hospital of Chengdu University of Traditional Chinese MedicineChengdu 610000China Department of ENTQuxian Traditional Chinese Medicine HospitalQuxian 635299China 

出 版 物：《Journal of Traditional Chinese Medicine》 (中医杂志（英文版）)

年 卷 期：2023年第43卷第5期

页      面：973-982页

核心收录：

学科分类：1005[医学-中医学] 100512[医学-针灸推拿学] 10[医学] 

基　　金：General Program of the National Natural Science Foundation of China:Regulatory Mechanism of Acupoint Catgut Embedding via Axonal Reflex on Neurogenic Inflammation in Allergic Rhinitis(No.81273985) General Program of the National Natural Science Foundation of China:the Study on the Mechanism of Acupoint Catgut Embedding Therapy for Allergic Rhinitis Based on the Coupling of"Acupoint Nasal Mucosal Sensory Nerve Dendritic Cells"(No.81473523) National Science and Technology Support Program for the Twelfth Five-Year Plan:the Study on Clinical Effect and Operation Standard of Catgut Embedding at Acupoints in Treating Allergic Rhinitis(No.2015BA I04B00) 

主　　题：rhinitis,allergic acupoint catgut embedding enzyme-linked immunosorbent assay immunoglobulin E interleukin-4 hippocampus toll-like receptor 2 

摘      要：OBJECTIVE:To investigate the effects of acupoint catgut embedding for 3 weeks on lung tissue,blood immunoglobulin E(IgE)and interleutin-4(IL-4),brain tissue microglia x-42(OX-42)and toll-like receptor-2(TLR-2)in rats with allergic rhinitis of lung deficiency ***:Forty-five female Sprague-Dawley rats were randomly divided for two *** first time,they were randomly divided into model group and blank group(Group C)according to 2∶1,and the second time,the model group were randomly divided into model control group(Group B)and intervention treatment group(Group A)according to 1∶1.15 in each *** Group A and Group B,the lung deficiency model was made bysulfur–moxa fumigation,and then the allergic rhinitis model was established byovalbumin(OVA)sensitization.Then catgut embedding was performed at acupoints in Group A and not in Group *** 3 weeks,collect lung tissue samples for hematoxylin-eosin staining,then take blood to observe the concentration of IgE and IL-4,and finally take brain tissue to observe the results of OX-42 and ***:IgE level(μg/m L)was(3.11±0.20)in the Group A,(4.19±0.44)in the Group B,and(2.29±0.30)in the Group C(all P0.001).IL-4 level(pg/mL)was(14.2±0.7)in the Group A,(18.6±2.4)in the Group B,and(11.4±1.2)for the Group C(all P0.001).The mean OD for OX-42 is(0.1728±0.0016)in the Group A,(0.1810±0.0046)in the Group B and(0.1674±0.0025)in the Group C(all P0.001).CONCLUSION:Although 3 weeks of acupoint catgut embedding already showed obvious efficacy on rats with allergic rhinitis,the allergic reaction in the body still *** achieve further treatment,prolonging the catgut embedding time is necessary.