Effect of Acupressure Therapy on Anti-inflammatory Mechanism in Obesity-induced IR Rats
作者机构：College of Acupuncture and TuinaChangchun University of Chinese MedicineChangchun 130117China
出 版 物：《Medicinal Plant》 (药用植物：英文版)
年 卷 期：2023年第14卷第4期
页 面：62-64页
学科分类：1005[医学-中医学] 100512[医学-针灸推拿学] 10[医学]
基 金：Supported by National Natural Science Foundation of China(82174525) Jilin Science and Technology Development Plan Project(YDZJ202201ZYTS195) Jilin Natural Science Foundation(YDZJ202301ZYTS469) Jilin Traditional Chinese Medicine Science and Technology Project in 2022(2022128) 2023 Youth Outstanding Discipline Backbone Training Project of Changchun University of Chinese Medicine(202304)
主 题：Massage Acupressure therapy Obesity and insulin resistance Anti-inflammatory mechanism
摘 要：[Objectives] To study the effect of acupressure therapy on anti-inflammatory mechanism in obesity-induced IR rats. [Methods] 10 rats were randomly selected and fed with normal diet as blank group, and the remaining 30 rats were fed with high-fat diet for 8 weeks. The obesity-induced IR model was induced and divided into two groups: model group and acupressure group. The acupressure group was treated by acupressure therapy three times a week for 6 weeks;the model group was taken 3 times at the same time every week, and the supine binding experiment lasted for 10 min for 6 weeks. Morphological observation was carried out before and after the experiment, mainly observing the general conditions and body weight. After the last intervention, the animals were killed and samples were collected. Western Blot method was used to detect the expression of TNF-α and IL-6 protein in adipose tissue of the three groups. [Results] Compared with the blank group, the expression of TNF-α and IL-6 protein in adipose tissue of the model group increased significantly ( P 0.01);compared with the model group, the expression of TNF-α and IL-6 protein in adipose tissue of the acupressure group decreased significantly ( P 0.01). [Conclusions] After intervening in the obesity-induced IR rats with acupressure method, the status of insulin resistance in obese rats was improved by inhibiting the expression of inflammatory factors.
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