Interaction between mucus layer and gut microbiota in non-alcoholic fatty liver disease:Soil and seeds

作     者：Binbin Zhang Jie Li Jinlong Fu Li Shao Luping Yang Junping Shi 

作者机构：Department of Translational Medicine PlatformThe Affiliated Hospital of Hangzhou Normal UniversityHangzhouZhejiang 310015China Department of School of Life SciencesZhejiang University of Traditional Chinese MedicineHangzhouZhejiang 310053China Department of Infectious DiseaseNanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu 210008China Department of School of Clinical MedicineHangzhou Normal UniversityHangzhouZhejiang 311121China Department of Fourth School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang 310053China Department of Infectious&Hepatology DiseasesMetabolic Disease CenterThe Affiliated Hospital of Hangzhou Normal UniversityHangzhouZhejiang 310015China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2023年第136卷第12期

页      面：1390-1400页

核心收录：

学科分类：1002[医学-临床医学] 10[医学] 

基　　金：National Natural Science Funds of China(Nos.82204827,81970545,and 82170609) Zhejiang Provincial Basic Public Welfare Research Project(Nos.LQ23H270016 and LGF20H030010) Hangzhou Major Science and Technology Plan Project(No.20172016A02) Major Projects of Hangzhou Medical and Health Science and Technology Plan(No.0020191059) 

主　　题：Non-alcoholic fatty liver disease Gut microbiome Fecal microbiota transplantation Intestinal barrier Intestinal mucus layer 

摘      要：The intestinal mucus layer is a barrier that separates intestinal contents and epithelial cells,as well as acts as themucus layer-soilfor intestinal flora adhesion and colonization.Its structural and functional integrity is crucial to human health.Intestinal mucus is regulated by factors such as diet,living habits,hormones,neurotransmitters,cytokines,and intestinal flora.The mucus layer’s thickness,viscosity,porosity,growth rate,and glycosylation status affect the structure of the gut flora colonized on it.The interaction betweenmucus layer-soilandgut bacteria-seedis an important factor leading to the pathogenesis of non-alcoholic fatty liver disease(NAFLD).Probiotics,prebiotics,fecal microbiota transplantation(FMT),and wash microbial transplantation are efficient methods for managing NAFLD,but their long-term efficacy is poor.FMT is focused on achieving the goal of treating diseases by enhancing thegut bacteria-seed.However,a lack of effective repair and management of themucus layer-soilmay be a reason whyseedscannot be well colonized and grow in the host gut,as the thinning and destruction of themucus layer-soilis an early symptom of NAFLD.This review summarizes the existing correlation between intestinal mucus and gut microbiota,as well as the pathogenesis of NAFLD,and proposes a new perspective thatmucus layer-soilrestoration combined withgut bacteria-seedFMT may be one of the most effective future strategies for enhancing the long-term efficacy of NAFLD treatment.