Eosinophilic gastroenteritis: Pathogenesis, diagnosis, and treatment

作     者：Kaiwen Li Gechong Ruan Shuang Liu Tianming Xu Kai Guan Ji Li Jingnan Li 

作者机构：Department of GastroenterologyPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100005China Key Laboratory of Gut Microbiota Translational Medicine ResearchPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100005China Department of AllergyPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100005China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2023年第136卷第8期

页      面：899-909页

核心收录：

学科分类：1002[医学-临床医学] 10[医学] 

基　　金：National High Level Hospital Clinical Reseach Funding(No.2022-PUMCH-B-022) CAMS Innovation Fund for Medical Sciences(No.CIFMS2021-I2M-1-003) National key clinical specialty construction project(No.ZK108000) 

主　　题：Eosinophilic gastroenteritis Pathogenesis Diagnosis Treatment 

摘      要：Eosinophilic gastroenteritis(EGE)is a gastrointestinal disorder of unclear etiology that is characterized by eosinophilic infiltration of the stomach and small intestine,and consists of mucosal,muscular,and serosal subtypes.Eosinophilic infiltration of the gastrointestinal tract is a fundamental histopathological characteristic of EGE and is driven by several T-helper type 2(Th2)-dependent cytokines and induced by food allergy.Due to the lack of a diagnostic gold standard,EGE has a high rate of delayed diagnosis or misdiagnosis.However,several new diagnostic strategies have been developed,such as novel genetic biomarkers and imaging tests.Although dietary therapy and corticosteroids remain the common choices for EGE treatment,recent decades have seen the emergence of novel treatment alternatives,such as biologics that target particular molecules involved in the pathogenic process.Preliminary investigations and clinical trials have demonstrated the efficacy of biologics and provided additional insights for the era of refractory or corticosteroid-dependent EGE biologics.