Insulin resistance and the metabolism of branched-chain amino acids

作     者：Jingyi Lu Guoxiang Xie Weiping Jia Wei Jia 

作者机构：Shanghai Diabetes InstituteDepartment of Endocrinology and MetabolismShanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai Key Laboratory of Diabetes MellitusShanghai Clinical Center for DiabetesShanghai 200233China Center for Translational MedicineShanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai 200233China Center for Translational Biomedical ResearchUniversity of North Carolina at GreensboroNorth Carolina Research CampusKannapolisNC 28081USA 

出 版 物：《Frontiers of Medicine》 (医学前沿（英文版）)

年 卷 期：2013年第7卷第1期

页      面：53-59页

核心收录：

学科分类：1002[医学-临床医学] 07[理学] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：This work was supported by grants from the National Basic Research Program of China(973 Program,2011CB504001) the National Natural Science Foundation of China(Grant Nos.81100590 and 81170760). 

主　　题：branched-chain amino acids leucine isoleucine valine insulin resistance 

摘      要：Insulin resistance(IR)is a key pathological feature of metabolic syndrome and subsequently causes serious health problems with an increased risk of several common metabolic disorders.IR related metabolic disturbance is not restricted to carbohydrates but impacts global metabolic network.Branched-chain amino acids(BCAAs),namely valine,leucine and isoleucine,are among the nine essential amino acids,accounting for 35%of the essential amino acids in muscle proteins and 40%of the preformed amino acids required by mammals.The BCAAs are particularly responsive to the inhibitory insulin action on amino acid release by skeletal muscle and their metabolism is profoundly altered in insulin resistant conditions and/or insulin deficiency.Although increased circulating BCAA concentration in insulin resistant conditions has been noted for many years and BCAAs have been reported to be involved in the regulation of glucose homeostasis and body weight,it is only recently that BCAAs are found to be closely associated with IR.This review will focus on the recent findings on BCAAs from both epidemic and mechanistic studies.