Evaluation of anti-nociceptive activity of methanolic extract of Tecomaria capensis Thunb.(Bignoniaceae) leaves in rats

作     者：Saini NK Singhal M 

作者机构：Department of PharmacologyJaipur National University 

出 版 物：《Asian Pacific Journal of Tropical Medicine》 (亚太热带医药杂志（英文版）)

年 卷 期：2012年第5卷第10期

页      面：781-784页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 1002[医学-临床医学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by the management and faculty of Jaipur National University Jaipur Rajasthan India 

主　　题：Pain Writhing Tail-flick Tail-clip 

摘      要：Objective:To evaluate the ann-nociceptive activity of Tecomaria capensls(***) leaves extract(TCLE) using different models in rats by acetic acid induced writhing test,(b) tail-flick test(c) tail-clip ***:TCLE(100,300,1000 and 2000 mg/kg body wt.) was given to rats orally to observe acute toxicity for 14 *** test drug TCLE were given at dose of 100,200 and 500 mg/kg *** standard drug aspirin were given at a dose of 100 mg/kg ***:No mortality was reported even after 14 *** indicates that the methanol extract is safe up to a single dose of 2 000 mg/kg body weight TCLE(100,200 and 500 mg/kg p.o.) significandy inhibited abdominal constrictions(writhing) induced by acetic acid and increased the latency period in the tail flick and tail clip *** at the dose of 500 mg/kg showed significant anti-nociceptive activity compared to standard ***:The results of this study show that methanol extract of *** possesses anti-nociceptive activity which may be mediated by the central and peripheral mechanisms.