Enthesitis in patients with psoriatic arthritis: A nationwide data from the Chinese Registry of Psoriatic Arthritis (CREPAR)

作     者：Fan Yang Chaofan Lu Huilan Liu Lei Dou Yanhong Wang Hongbin Li Xinwang Duan Lijun Wu Yongfu Wang Xiuying Zhang Jian Xu Jinmei Su Dong Xu Jiuliang Zhao Qingjun Wu Mengtao Li Xiaomei Leng Xiaofeng Zeng 

作者机构：Department of Rheumatology and Clinical ImmunologyPeking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeNational Clinical Research Center for Dermatologic and Immunologic Diseases(NCRC-DID)Key Laboratory of Rheumatology and Clinical ImmunologyMinistry of EducationBeijing 100730China Department of Rheumatology and ImmunologyThe Second People’s Hospital of WuhuWuhuAnhui 241000China Department of Epidemiology and BiostatisticsInstitute of Basic Medical SciencesChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100005China The Division of RheumatologyThe Affiliated Hospital of Inner Mongolia Medical UniversityHohhotInner Mongolia 010110China Department of RheumatologyThe Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi 330006China Department of Rheumatology and ImmunologyThe People’s Hospital of the Xinjiang Uygur Autonomous RegionUrumqiXinjiang 830001China Department of RheumatologyFirst Affiliated Hospital of Baotou Medical CollegeBaotouInner Mongolia 014010China Department of RheumatologyZibo Central HospitalZiboShandong 255036China Department of RheumatologyThe First Affiliated Hospital of Kunming Medical UniversityKunmingYunnan 650032China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2023年第136卷第8期

页      面：951-958页

核心收录：

学科分类：1002[医学-临床医学] 10[医学] 100206[医学-皮肤病与性病学] 

基　　金：National Basic Research Program of China(973 Program)(No.2014CB541801) 

主　　题：Enthesitis Psoriatic arthritis Registry 

摘      要：Background:The clinical features of enthesitis in patients with psoriatic arthritis(PsA)have been reported in some Western countries,but data in China are very limited.This study aimed to describe the characteristics of enthesitis in Chinese patients with PsA and compared them with those in other cohorts.Methods:Patients with PsA enrolled in the Chinese Registry of Psoriatic Arthritis(CREPAR)(December 2018 to June 2021)were included.Data including demographics,clinical characteristics,disease activity measures,and treatment were collected at enrollment.Enthesitis was assessed by the Spondyloarthritis Research Consortium of Canada(SPARCC),Maastricht ankylosing spondylitis enthesitis score(MASES),and Leeds enthesitis index(LEI)indices.A multivariable logistic model was used to identify factors related to enthesitis.We also compared our results with those of other cohorts.Results:In total,1074 PsA patients were included,308(28.7%)of whom had enthesitis.The average number of enthesitis was 3.3±2.8(range:1.0–18.0).More than half of the patients(165,53.6%)had one or two tender entheseal sites.Patients with enthesitis had an earlier age of onset for both psoriasis and arthritis,reported a higher proportion of PsA duration over 5 years,and had a higher percentage of axial involvement and greater disease activity.Multivariable logistic regression showed that axial involvement(odds ratio[OR]2.21,95%confidence interval[CI],1.59–3.08;P0.001),psoriasis area and severity index(PASI)(OR:1.03,95%CI:1.01–1.04;P=0.002),and disease activity score 28-C reactive protein(DAS28-CRP)(OR:1.25,95%CI:1.01–1.55;P=0.037)were associated with enthesitis.Compared with the results of other studies,Chinese patients with enthesitis had a younger age,lower body mass index(BMI),a higher rate of positive human leukocyte antigen(HLA)-B27,more frequent dactylitis,and a higher proportion of conventional synthetic disease-modifying antirheumatic drugs’(csDMARDs)use.Conclusions:Enthesitis is a common condition among Chinese patients with PsA.It is important to evaluate entheses in both peripheral and axial sites.