Global prevalence of drug-resistant tuberculosis: a systematic review and meta-analysis

作     者：Nader Salari Amir Hossein Kanjoori Amin Hosseinian-Far Razie Hasheminezhad Kamran Mansouri Masoud Mohammadi Nader Salari;Amir Hossein Kanjoori;Amin Hosseinian-Far;Razie Hasheminezhad;Kamran Mansouri;Masoud Mohammadi

作者机构：Department of BiostatisticsSchool of HealthKermanshah University of Medical SciencesKermanshahIran Sleep Disorders Research CenterKermanshah University of Medical SciencesKermanshahIran Student Research CommitteeKermanshah University of Medical SciencesKermanshahIran Department of Business Systems&OperationsUniversity of NorthamptonNorthamptonUK Medical Biology Research CenterKermanshah University of Medical SciencesKermanshahIran Cellular and Molecular Research CenterGerash University of Medical SciencesGerashIran 

出 版 物：《Infectious Diseases of Poverty》 (贫困所致传染病（英文）)

年 卷 期：2023年第12卷第3期

页      面：1-12页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：By Deputy for Research and Technology Kermanshah University of Medical Sciences(IR)(50002460). 

主　　题：Prevalence Drug-resistant tuberculosis Burden Outbreak TB 

摘      要：Background Tuberculosis is a bacterial infectious disease,which affects different parts of a human body,mainly lungs and can lead to the patient’s death.The aim of this study is to investigate the global prevalence of drug-resistant tuberculosis using a systematic review and meta-analysis.Methods In this study,the PubMed,Scopus,Web of Science,Embase,ScienceDirect and Google Scholar repositories were systematically searched to find studies reporting the global prevalence of drug-resistant tuberculosis.The search did not entail a lower time limit,and articles published up until August 2022 were considered.Random effects model was used to perform the analysis.The heterogeneity of the studies was examined with the I^(2) test.Data analysis was conducted within the Comprehensive Meta-Analysis software.Results In the review of 148 studies with a sample size of 318,430 people,the I^(2) index showed high heterogeneity(I^(2)=99.6),and accordingly random effects method was used to analyze the results.Publication bias was also examined using the Begg and Mazumdar correlation test which indicated the existence of publication bias in the studies(P=0.008).According to our meta-analysis,the global pooled prevalence of multi-drug resistant TB is 11.6%(95%CI:9.1–14.5%).Conclusions The global prevalence of drug-resistant tuberculosis was found to be very high,thus health authorities should consider ways to control and manage the disease to prevent a wider spread of tuberculosis and potentially subsequent deaths.