Research progress on reactive oxygen species production mechanisms in tumor sonodynamic therapy

作     者：He-Qin Dong Xiao-Feng Fu Min-Yan Wang Jiang Zhu 

作者机构：School of MedicineShaoxing UniversityShaoxin 312000Zhejiang ProvinceChina Department of UltrasoundWomen's HospitalZhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina 

出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)

年 卷 期：2023年第11卷第22期

页      面：5193-5203页

核心收录：

学科分类：0202[经济学-应用经济学] 02[经济学] 020205[经济学-产业经济学] 

基　　金：the National Natural Science Foundation of China,No.82272004 and No.81974470 the Nature Science Foundation of Zhejiang Province,No.LZ22H180001 

主　　题：Sonodynamic therapy Reactive oxygen species Hypoxic Tumor Microenvironment Sonosensitizer 

摘      要：In recent years,because of the growing desire to improve the noninvasiveness and safety of tumor treatments,sonodynamic therapy has gradually become a popular research ***,due to the complexity of the therapeutic process,the relevant mechanisms have not yet been fully *** of the widely accepted possibilities involves the effect of reactive oxygen *** this review,the mechanism of reactive oxygen species production by sonodynamic therapy(SDT)and ways to enhance the sonodynamic production of reactive oxygen species are ***,the clinical application and limitations of SDT are *** conclusion,current research on sonodynamic therapy should focus on the development of sonosensitizers that efficiently produce active oxygen,exhibit biological safety,and promote the clinical transformation of sonodynamic therapy.