Antiviral stereoisomers of 3,5-bis(2-hydroxybut-3-en-1-yl)-1,2,4-thiadiazole from the roots of Isatis indigotica

作     者：Ming-Hua Chen Sheng Lin Ya-Nan Wang Cheng-Gen Zhu Yu-Huan Li Jian-Dong Jiang Jian-Gong Shi 

作者机构：State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences and Peking Union Medical College 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2016年第27卷第5期

页      面：643-648页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 0703[理学-化学] 10[医学] 

基　　金：Financial support from the National Natural Science Foundation of China (Nos. 81373287 and 30825044) the Beijing Excellent Talent Training Project (No. 2013D009008000002) the National Science and Technology Project of China (Nos. 2012ZX09301002002 and 2011ZX09307-002-01) 

主　　题：Isatis indigoticaCruciferae3.5-Bis( 2-hydroxybut-3-en- 1 -yl)-1 2 4-thiadiazole Stereoisomer Insatindigothiadiazoles A-DAntiviral activity 

摘      要：Four stereoisomers of 3,5-bis（2-hydroxybut-3-en-1-yl）-l,2,4-thiadiazole, named insatindigothiadia- zoles A-D （1a-1d）, were isolated from the roots oflsatis indigotica. Their structures were determined by spectroscopic analysis; specifically, the absolute configurations were assigned by using the MPA determination rule based on △δrs values of MPA esters, and supported by electronic CD （ECD） calculations. Proposed biosynthetic pathways and preliminary investigations of the biological activities of la-1d against influenza virus A （H3N2）, Coxsackie virus B3, and/or HSV-1 are also discussed.