Anticancer Activity of Diosgenin and Its Molecular Mechanism

作     者：REN Qun-li WANG Qian ZHANG Xin-qun WANG Miao HU Huan TANG Jun-jie YANG Xiong-tong RAN Ying-hui LIU Huan-huan SONG Zhi-xing LIU Jian-guo LI Xiao-lan 

作者机构：Special Key Laboratory of Microbial Resources and Drug Development of Guizhou Higher Education InstitutionZunyi Medical UniversityZunyiGuizhou Province(563000)China School of StomatologyZunyi Medical UniversityZunyiGuizhou Province(563000)China Institute of Life SciencesZunyi Medical UniversityZunyiGuizhou Province(563000)China Zheng'an County People's HospitalZunyiGuizhou Province(563000)China School of Basic MedicineZunyi Medical UniversityZunyiGuizhou Province(563000)China 

出 版 物：《Chinese Journal of Integrative Medicine》 (中国结合医学杂志（英文版）)

年 卷 期：2023年第29卷第8期

页      面：738-749页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 1002[医学-临床医学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：the National Natural Science Foundation of China(No.31860076) Outstanding Young Talent Project of Zunyi Medical University(No.17zy-002) Technology Support Program of Zunyi(No.ZSKH-HZ-ZI-2020-88) Science and Technology Project of Zunyi[ZSKH-HZ(2020)No.60/55] Special Project of Zunyi Medical University for Academic New Talents[No.QKHPT(2018)5772-067/062] Guizhou Provincial Chinese Medicine Administration Project(No.QZYY-2019-064) 

主　　题：diosgenin steroidal sapogenin anticancer molecular mechanism biological activity 

摘      要：Diosgenin, a steroidal sapogenin, obtained from Trigonella foenum-graecum, Dioscorea, and Rhizoma polgonati, has shown high potential and interest in the treatment of various cancers, such as oral squamous cell carcinoma, laryngeal cancer, esophageal cancer, liver cancer, gastric cancer, lung cancer, cervical cancer, prostate cancer, glioma, and leukemia. This article aims to provide an overview of the in vivo, in vitro,and clinical studies reporting the diosgenin’s anticancer effects. Preclinical studies have shown promising effects of diosgenin on inhibiting tumor cell proliferation and growth, promoting apoptosis, inducing differentiation and autophagy, inhibiting tumor cell metastasis and invasion, blocking cell cycle, regulating immunity and improving gut microbiome. Clinical investigations have revealed clinical dosage and safety property of diosgenin. Furthermore, in order to improve the biological activity and bioavailability of diosgenin, this review focuses on the development of diosgenin nano drug carriers, combined drugs and the diosgenin derivatives. However, further designed trials are needed to unravel the diosgenin’s deficiencies in clinical application.